Volume 23, Issue 10
مرور بر اساس
ارسال های اخیر
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Evaluation the interaction of ABC multidrug transporter MDR1 with thymoquinone: substrate or inhibitor?
(Mashhad University of Medical Sciences, 2020-10-01)Objective(s): Thymoquinone (TQ) has valuable medical properties like anticancer effects. Development of multidrug resistance (MDR) phenotype is one of the most important factors in failure of ...
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Calcium sensing receptor involving in therapy of embryonic stem cell transplantation alleviates acute myocardial infarction by inhibiting apoptosis and oxidative stress in rats
(Mashhad University of Medical Sciences, 2020-10-01)Objective(s): The aims of the present study were to investigate the expression of calcium sensing receptor (CaSR) at different times in acute myocardial infarction (AMI) rat myocardial tissue after ...
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<i>In vitro</i> combination therapy of pathologic angiogenesis using anti-vascular endothelial growth factor and anti-neuropilin-1 nanobodies
(Mashhad University of Medical Sciences, 2020-10-01)Objective(s): Emergence of resistant tumor cells to the current therapeutics is the main hindrance in cancer treatment. Combination therapy, which mixes two or more drugs, is a way to overcome ...
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Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain
(Mashhad University of Medical Sciences, 2020-10-01)Objective(s): Prevention of inflammation in early stages will be useful in maintaining vitality of the organism. The objective of this study was to evaluate the effects of doxycycline (DOX) or ...
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Evaluation of the genetic relatedness of <i>Bacteroides fragilis</i> isolates by TRs analysis
(Mashhad University of Medical Sciences, 2020-10-01)Objective(s): Human gastrointestinal tract harbors a variety of bacteria with vital roles in human health. Bacteroides fragilis is considered one of the dominant constituents of gut microflora ...
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Antibiotic resistance and typing of agr locus in <i>Staphylococcus aureus</i> isolated from clinical samples in Sanandaj, Western Iran
(Mashhad University of Medical Sciences, 2020-10-01)Objective(s): Infections by Staphylococcus aureus remain an important health problem. The aims were to detect mecA, staphylococcal cassette chromosome mec (SCCmec), accessory gene regulator (agr), and integrons in S. aureus ...
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Aberrant effect of genistein on placenta development expressed through alteration in transforming growth factor-β1 and alkaline phosphatase across the maternal serum, the placenta and the amniotic fluid
(Mashhad University of Medical Sciences, 2020-10-01)Objective(s): The mechanism via which genistein, the major isoflavone content of soya, adversely influenced placenta and fetal development was evaluated in pregnant laboratory rats.
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Mesoporous silica SBA-15 decreases hyperammonemia and affects the gene expression of mitogen-activated protein kinases in the prefrontal cortex of rats with bile duct ligation
(Mashhad University of Medical Sciences, 2020-10-01)Objective(s): We aim to examine possible ammonia lowering effects of mesoporous silica SBA-15 in rats after the common bile duct ligation (BDL). We also evaluate the effect of SBA-15 treatments ...
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Stimulation of dendritic cell functional maturation by capsid protein from chikungunya virus
(Mashhad University of Medical Sciences, 2020-10-01)Objective(s): Chikungunya virus (ChikV) infection is characterized by persistent infection in joints and lymphoid organs. The ChikV Capsid protein plays an important role in regulating virus ...
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Prevalence of resistance and toxin genes in community-acquired and hospital-acquired methicillin-resistant <i>Staphylococcus aureus</i> clinical isolates
(Mashhad University of Medical Sciences, 2020-10-01)Objective(s): Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major health hazards and became of greater public health concern since the emergence of community-acquired MRSA. This ...
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Effect of soy consumption on liver enzymes, lipid profile, anthropometry indices, and oxidative stress in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials
(Mashhad University of Medical Sciences, 2020-10-01)The present systematic review and meta-analysis was conducted to investigate the effects of soy intake on liver enzymes, lipid profile, anthropometry indices, and oxidative stress in non-alcoholic fatty liver disease ...
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Characterization of the first highly predatory Bdellovibrio bacteriovorus from Iran and its potential lytic activity against principal pathogenic <i>Enterobacteriaceae</i>
(Mashhad University of Medical Sciences, 2020-10-01)Objective(s): Bdellovibrio-and-like organisms (BALOs) are predatory prokaryotes that attack and kill other Gram-negative bacteria for growth and reproduction. This study describes the isolation, ...
