مرور Volume 21, Issue 12 بر اساس عنوان
در حال نمایش موارد 1 - 16 از 16
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Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): Methamphetamine is a stimulant compound that penetrates readily into the central nervous system. Repeated exposure to methamphetamine leads to damage in the dopaminergic and serotonergic ...
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Effect of apelin on cardiac contractility in acute reno-vascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): Apelin/APJ system plays an important role in the regulation of myocardial contractility (MC) and blood pressure. Opioid receptors (OPRs) are also important cardiovascular regulators ...
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Effect of gallic acid on chronic restraint stress-induced anxiety and memory loss in male BALB/c mice
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): Long-term exposure to stress leads to memory deficits and certain mood disorders such as depression and anxiety. We aimed to study the effect of gallic acid (GA) on chronic restraint ...
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Effect of ghrelin on serum metabolites in Alzheimer’s disease model rats; a metabolomics studies based on 1H-NMR technique
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): Alzheimer's disease (AD) is dysfunction of the central nervous system and as a neurodegenerative disease. The objective of this work is to investigate metabolic profiling in the serum ...
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The effects of casticin and myricetin on liver damage induced by methotrexate in rats
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): In this study, we evaluated the therapeutic effects of casticin and myricetin on liver damage induced by methotrexate in rats.Materials and Methods: ...
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Exposure to cell phone radiofrequency changes corticotrophin hormone levels and histology of the brain and adrenal glands in male Wistar rat
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): Nowadays, the electromagnetic field-emitting devices are used routinely in our lives. Controversial reports exist concerning the effects of mobile radiofrequency (RF) on different ...
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A glance at black cumin<i>(Nigella sativa)</i> and its active constituent, thymoquinone, in ischemia: a review
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): Black cumin (Nigella sativa) belonging to Ranunculaceae family has a long history of medicinal use in various folk and traditional systems of medicine, including Iranian traditional ...
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Histo-morphological and seminal evaluation of testicular parameters in diabetic rats under antiretroviral therapy: interactions with <i>Hypoxis hemerocallidea</i>
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): Broad range of metabolic changes associated with highly active antiretroviral therapy (HAART) has been reported over decades including reproductive perturbations. The current study ...
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Involvement of central opiate receptors in modulation of centrally administered oxytocin-induced antinociception
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): Oxytocin is involved in modulation of many brain-mediated functions. In the present study, we investigated the central effects of oxytocin and its receptor antagonist, atosiban on ...
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The protective effect of propofol on hydrogen peroxide-induced human esophageal carcinoma via blocking the Wnt/β-catenin signaling pathway
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): To analyze the potential influences of propofol on the oxidative stress of H2O2-induced human esophageal squamous cell carcinoma (ESCC) Eca109 cell through mediating the Wnt/β-catenin ...
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The role of calcium channel blockers in wound healing
(Mashhad University of Medical Sciences, 2018-12-01)Wound healing is a natural response to restore the injured tissue to normal. Wound healing is also complicated process involving different cellular, molecular and biochemical mechanisms and various types of cytokines and ...
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The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): To benefit from reproduction and deal with challenges in the environmental conditions, animals must adapt internal physiology to maximize the reproduction rate. Maladaptive variations ...
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Serological, pathological and scintigraphic assessment of Hemiscorpius lepturus effects on renal dysfunction in rats
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): Hemiscorpius lepturus is one of the dangerous scorpions of Iran leading to acute kidney injury (AKI) especially in infants. The purpose of this animal study was to compare the ...
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Sleep deprivation disrupts striatal anti-apoptotic responses in 6-hydroxy dopamine-lesioned parkinsonian rats
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): The present study was conducted to examine the effect of sleep deprivation (SD) on the anti-apoptotic pathways in Parkinsonian rats. Materials and Methods: ...
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Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): Obstructive sleep apnea (OSA) is confirmed to cause lesions in multiple organs, especially in the lung tissue. Tempol is an antioxidant that has been reported to restrain inflammation ...
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Wild pistachio <i>(Pistacia atlantica mutica)</i> oil improve metabolic syndrome features in rats with high fructose ingestion
(Mashhad University of Medical Sciences, 2018-12-01)Objective(s): Metabolic syndrome is a multiplex risk factor for diabetes and cardiovascular disease. Since some dietary fats such as mono-unsaturated fatty acids (MUFA) modify metabolic syndrome ...
