مرور Volume 18, Issue 12 بر اساس تاریخ انتشار
در حال نمایش موارد 1 - 13 از 13
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Repeated injections of orexin-A developed behavioral tolerance to its analgesic effects in rats
(Mashhad University of Medical Sciences, 2015-12-01)Objective(s):Reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. We investigated tolerance to anti-nociceptive effects of orexin-A, ...
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Effects of gamma oryzanol on factors of oxidative stress and sepsis-induced lung injury in experimental animal model
(Mashhad University of Medical Sciences, 2015-12-01)Objective (s): There is corroborating evidence to substantiate redox imbalance and oxidative stress in sepsis that finally leads to organ damage or even death. Gamma oryzanol (GO) is one of the major bioactive ...
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Improvement effect of Lycium barbarum polysaccharide on sub-health mice
(Mashhad University of Medical Sciences, 2015-12-01)Objective(s):Sub-health has been described as a chronic condition of unexplained deteriorated physiological function, which falls between health and illness. In the present study, we evaluated the effects ...
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SCN1A and SCN1B gene polymorphisms and their association with plasma concentrations of carbamazepine and carbamazepine 10, 11 epoxide in Iranian epileptic patients
(Mashhad University of Medical Sciences, 2015-12-01)Objective (s): From a genetic point of view, epilepsy is a polygenic multifactorial syndrome. The SCN1A and B genes belong to a family of genes that provide instructions for making sodium channels. Understanding ...
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The effects of long-term leptin administration on morphometrical changes of mice testicular tissue
(Mashhad University of Medical Sciences, 2015-12-01)Objective(s):Leptin is a novel and interesting hormone for anyone trying to lose weight, but its effects on male gonad structure in longitudinal study is unknown. The present study was designed to explore ...
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Case-control study on peroxisome proliferator-activated receptor gamma polymorphism and interaction with HDL on essential hypertension in Chinese Han
(Mashhad University of Medical Sciences, 2015-12-01)Objective(s): To investigate the association of single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptors gamma (PPARG) with essential hypertension (EH) and additional role of gene– ...
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Mesenchymal stem cells can survive on the extracellular matrix-derived decellularized bovine articular cartilage scaffold
(Mashhad University of Medical Sciences, 2015-12-01)Objective (s): The scarcity of articular cartilage defect to repair due to absence of blood vessels and tissue engineering is one of the promising approaches for cartilage regeneration. The objective of this study ...
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Effects of cardiopulmonary bypass on lung nuclear factor-kappa B activity, cytokine release, and pulmonary function in dogs
(Mashhad University of Medical Sciences, 2015-12-01)Objective(s): To study the effect of cardiopulmonary bypass (CPB) on nuclear factor-kappa B (NF-кB) and cytokine expression and pulmonary function in dogs. Materials and Methods: Twelve male mongrel ...
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Deregulation of miR-21 and miR-155 and their putative targets after silibinin treatment in T47D breast cancer cells
(Mashhad University of Medical Sciences, 2015-12-01)Objective(s):MicroRNAs (miRNAs) are a class of short RNAs that control the biological processes including cell proliferation, apoptosis and development. Aberrant expression of miRNAs was determined in the ...
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Fluorescence spectra of cardiac myosin and in vivo experiment: studies on daunorubicin-induced cardiotoxicity
(Mashhad University of Medical Sciences, 2015-12-01)Objective(s):The objective of this study was to investigate the interaction of daunorubicin (DNR) and cardiac myosin (CM) and the changes in mice hearts to exhibit DNR-induced cardiotoxicity . Materials ...
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Razi’s Al-Hawi and saffron (<I>Crocus sativus</I>): a review
(Mashhad University of Medical Sciences, 2015-12-01)Traditional knowledge can be used as a source for development of new medicines. In the present study, we compare the data on saffron in Razi's Al-Hawi book with modern scientific studies. A computerized search of published ...
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Cholesterol suppresses antimicrobial effect of statins
(Mashhad University of Medical Sciences, 2015-12-01)Objective(s):Isoprenoid biosynthesis is a key metabolic pathway to produce a wide variety of biomolecules such as cholesterol and carotenoids, which target cell membranes. On the other hand, it has been reported ...
