Volume 23, Issue 7
مرور بر اساس
ارسال های اخیر
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Carvacrol and <i>Zataria multiflora</i> influenced the PPARγ agonist effects on systemic inflammation and oxidative stress induced by inhaled paraquat in rat
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): The effects of PPAR-γ agonist alone and in combination with carvacrol and Zataria multiflora on inhaled paraquat (PQ) induced-systemic inflammation and oxidative stress were examined.
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Human Wharton’s jelly mesenchymal stem cells-derived secretome could inhibit breast cancer growth <i>in vitro</i> and <i>in vivo</i>
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): Controversial results have been reported regarding the anti-tumor properties of extracellular vesicles derived from mesenchymal stem cells (MSCs). The present study was conducted to ...
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Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): The aim of this study was to investigate the effect of curcumin on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and its underlying potential ...
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Preparation and characterization of bear bile-loaded pH sensitive <i>in-situ</i> gel eye drops for ocular drug delivery
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): In this study, a stable bear bile-loaded pH sensitive in-situ eye drop gel was prepared for sustain delivery and enhanced therapeutic application. Materials and ...
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Point-of-care detection of <i>Escherichia coli</i> O157:H7 in water using AuNPs-based aptasensor
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): Access to safe drinking and irrigation water has always been one of the major human concerns worldwide. Thus, rapid, sensitive, and inexpensive approaches for pathogenic bacteria ...
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Genotypic and phenotypic characterization of enteroaggregative <i>Escherichia coli</i> (EAEC) isolates from diarrheic children: An unresolved diagnostic paradigm exists
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): The enteroaggregative Escherichia coli (EAEC) has been one of the most intriguing emerging bacterial pathogens in children that occur both in developing countries and the industrial ...
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A new DNA vaccine expressing HspX-PPE44-EsxV fusion antigens of <i>Mycobacterium tuberculosis</i> induced strong immune responses
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): Infection with tuberculosis (TB) is regarded as a major health issue. Due to the emergence of antibiotic resistance during TB treatment, prevention via vaccination is one of the most ...
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Electroacupuncture reduces chronic fibromyalgia pain through attenuation of transient receptor potential vanilloid 1 signaling pathway in mouse brains
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): Fibromyalgia pain is a mysterious clinical pain syndrome, characterized by inflammation in the brain, whose molecular mechanisms are still unknown. Females are more commonly affected ...
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Anti-cancer properties of <i>Escherichia coli</i> Nissle 1917 against HT-29 colon cancer cells through regulation of Bax/Bcl-xL and AKT/PTEN signaling pathways
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): Chemotherapies used to treat colon cancer might often fail due to the emergence of chemoresistance and side effects. Escherichia coli Nissle 1917 (EcN) is a beneficial probiotic, ...
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Comparison of the effects of intramyocardial and intravenous injections of human mesenchymal stem cells on cardiac regeneration after heart failure
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): Existing studies have demonstrated that intravenous and intramyocardial-administrated mesenchymal stem cells (MSCs) lead to tissue repair after cardiac disorders. We compared the ...
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Effects of 8-hydroxyquinoline-coated graphene oxide on cell death and apoptosis in MCF-7 and MCF-10 breast cell lines
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): Breast cancer is a devastating disease related to women. The anticancer properties of 8-hydroxyquinoline (8HQ) and the increasing use of graphene oxide (GO), as a drug delivery system ...
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Trastuzumab increases pulmonary vein arrhythmogenesis through modulating pulmonary vein electrical and conduction properties via phosphatidylinositol 3-kinase signaling
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): Drug-induced atrial fibrillation (AF) is considered an adverse effect of chemotherapeutic drugs. AF is a crucial risk factor for stroke, heart failure, myocardial infarction, and ...
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Thymoquinone: From <i>Nigella sativa</i> to a protective pharmacological compound in managing opioid dependence and amphetamine type stimulant issues
(Mashhad University of Medical Sciences, 2020-07-01)Opioids, amphetamines, and other types of substances have been widely abused around the world. Opioid dependence and tolerance are two distinct phenomena that have been associated with substance abuse issues. The management ...
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Evaluation of CD133 and CD56/NCAM expression in Wilms tumor and their association with prognostic factors
(Mashhad University of Medical Sciences, 2020-07-01)Objective(s): To validate certain markers for cancer stem cell populations and their clinical importance in Wilms tumor (WT)Materials and Methods: Immunohistochemical ...
