مرور Volume 22, Issue 3 بر اساس تاریخ انتشار
در حال نمایش موارد 1 - 13 از 13
-
Association of rs712 polymorphism in a let-7 microRNA-binding site of KRAS gene with colorectal cancer in a Mexican population
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): The rs712 polymorphism in a let-7 microRNA-binding site at KRAS gene has been associated with cancer. To examine its association with rs712 polymorphism, we analyzed Mexican individuals ...
-
Reno-protective effect of <i>Rheum turkestanicum</i> against gentamicin-induced nephrotoxicity
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): Gentamicin belongs to the family of aminoglycoside antibiotics and is a preferred drug in developing countries because of its low cost, availability, and potent effects against ...
-
Anticonvulsant and ameliorative effects of pioglitazone on cognitive deficits, inflammation and apoptosis in the hippocampus of rat pups exposed to febrile seizure
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): Pioglitazone (PGZ), a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, has significant neuroprotective effects and has been reported to regulate inflammatory ...
-
Pharmacological effects of gallic acid in health and disease: A mechanistic review
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): Gallic acid is a natural phenolic compound found in several fruits and medicinal plants. It is reported to have several health-promoting effects. This review aims to summarize the ...
-
The effect of alpha linolenic acid on tracheal responsiveness, lung inflammation and immune markers in sensitized rats
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): The effects of alpha linolenic acid (ALA) on tracheal responsiveness (TR), total protein (TP), phospholipase A2 (PLA2), immunoglobulin E (IgE), interleukin 4 (IL-4), interferon gamma ...
-
Molecular mechanisms regulating immune responses in thromboangiitis obliterans: a comprehensive review
(Mashhad University of Medical Sciences, 2019-03-01)Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis of the disease, however, the ...
-
Clonal dissemination of <i>Staphylococcus aureus</i> isolates causing nosocomial infections, Tehran, Iran
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): In the current research, the prevalence of Staphylococcus aureus clones and genes encoding antimicrobial resistance and toxins were examined among 120 S. aureus strains from nosocomial ...
-
Effect of IL-2 co-expressed or co-inoculated with immuno-dominant epitopes from VP1 protein of FMD virus on immune responses in BALB/c mice
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): The results of studies on vaccine development for foot-and-mouth disease (FMD) virus show that the use of inactivated vaccines for FMD virus is not completely effective. Novel ...
-
Effect of crocin on cardiac antioxidants, and hemodynamic parameters after injuries induced by hepatic ischemia-reperfusion in rats
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): This research aimed to test the impact of liver ischemia/reperfusion (IR) insult on the activity of antioxidant enzymes, functional enzymes, histological, and hemodynamic parameters ...
-
Anti-diabetic effect of loganin by inhibiting FOXO1 nuclear translocation via PI3K/Akt signaling pathway in INS-1 cell
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): JiangTangXiaoKe (JTXK) granule, a Chinese traditional herbal formula, has been clinically used and demonstrated to be beneficial in controlling high glucose and to relieve the symptoms ...
-
Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): Curcuminoids, comprising curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), are bioactive phytochemicals with numerous pharmacological effects. Oral biological ...
-
Therapeutic effect of valsartan against doxorubicin-induced renal toxicity in rats
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): Doxorubicin (DXR)-induces glomerular atrophy and fibrosis in rat kidneys. The objective of the current study was to investigate the protective effects of valsartan on DXR-induced ...
-
Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats
(Mashhad University of Medical Sciences, 2019-03-01)Objective(s): Bisphenol A (BPA) as a synthetic compound is applied in many plastic industries. BPA has been reported to have endocrine-disrupting feature with cytotoxic effects. The study aimed ...



