Volume 21, Issue 2
مرور بر اساس
ارسال های اخیر
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Immunogenicity of heparin-binding hemagglutinin expressed by Pichia pastoris GS115 strain
(Mashhad University of Medical Sciences, 2018-02-01)Objective(s): Heparin-binding hemagglutinin (HBHA), a mycobacterial cell surface protein, mediates adhesion to nonphagocytic cells and the dissemination of Mycobacterium tuberculosis ...
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Anti-inflammatory activity and chemical composition of Pycnocycla bashagardiana fruit’s essential oil in animal models
(Mashhad University of Medical Sciences, 2018-02-01)Objective(s): Pycnocycla bashagardiana is an endemic species found only in Iran. Due to the presence of myristicin as the major component of the fruit's oil we were prompted to assess the ...
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S100A9 aggravates bleomycin-induced dermal fibrosis in mice via activation of ERK1/2 MAPK and NF-κB pathways
(Mashhad University of Medical Sciences, 2018-02-01)Objective(s): This study aims to investigate the pathogenicity and possible mechanisms of S100A9 function in mice models of scleroderma. Materials and Methods: The ...
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CRISPR/Cas9, a new approach to successful knockdown of ABCB1/P-glycoprotein and reversal of chemosensitivity in human epithelial ovarian cancer cell line
(Mashhad University of Medical Sciences, 2018-02-01)Objective(s): Multidrug resistance (MDR) is a major obstacle in the successful chemotherapy of ovarian cancer. Inhibition of P-glycoprotein (P-gp), a member of ATP-binding cassette (ABC) transporters, ...
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Comparison of the efficacy of Piascledine and transforming growth factor β1 on chondrogenic differentiation of human adipose-derived stem cells in fibrin and fibrin-alginate scaffolds
(Mashhad University of Medical Sciences, 2018-02-01)Objective(s):The aim of this study was to compare the chondrogenic induction potential of Piascledine and TGF-β1 on adipose-derived stem cells (ADSCs) in fibrin and fibrin-alginate scaffolds.
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Ascorbic acid augments colony spreading by reducing biofilm formation of methicillin resistant Staphylococcus aureus
(Mashhad University of Medical Sciences, 2018-02-01)Objective(s):Staphylococcus aureus is a Gram-positive pathogen, well known for its resistance andversatile lifestyle. Under unfavourable conditions, it adapts biofilm mode of ...
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In vivo activity assessment of some Tanacetum species used as traditional wound healer along with identification of the phytochemical profile by a new validated HPLC method
(Mashhad University of Medical Sciences, 2018-02-01)Objective(s): Tanacetum species are traditionally used as insecticide, and externally wound healer as well as for anti-inflammatory and antihistaminic properties. The in vivo ...
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Hypericin-photodynamic therapy inhibits proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes cell line MH7A
(Mashhad University of Medical Sciences, 2018-02-01)Objective(s): To elucidate the effects and potential mechanisms of hypericin-photodynamic therapy (HYP-PDT) for treating the human rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) MH7A ...
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Evaluation of Tnf-α and Il-6 mRNAs expressions in visceral and subcutaneous adipose tissues of polycystic ovarian rats and effects of resveratrol
(Mashhad University of Medical Sciences, 2018-02-01)Objective(s): Some studies suggest that chronic low-grade inflammation is involved in insulin resistance in polycystic ovary syndrome (PCOS). This study assessed possible involvement of alteration ...
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Potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against tuberculosis: A systematic review
(Mashhad University of Medical Sciences, 2018-02-01)Objective(s): Production of effective tuberculosis (TB) vaccine is necessity. However, the development of new subunit vaccines is faced with concerns about their weak immunogenicity. To overcome ...
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Women with hereditary breast cancer predispositions should avoid using their smartphones, tablets and laptops at night
(Mashhad University of Medical Sciences, 2018-02-01)Breast cancer is the most common malignancy among women, both in the developed and developing countries. Women with mutations in the BRCA1 and BRCA2 genes have an increased risk of breast and ovarian cancers. Recent studies ...
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Administration of melatonin protects against acetylsalicylic acid-induced impairment of male reproductive function in mice
(Mashhad University of Medical Sciences, 2018-02-01)Objective(s): Melatonin, an important hormone secreted by the epiphysis, is a powerful anti-oxidant with a high potential to neutralize medical toxins. The goal of this study was to demonstrate ...
