مرور Volume 20, Issue 1 بر اساس تاریخ انتشار
در حال نمایش موارد 1 - 14 از 14
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The cytotoxic effect of memantine and its effect on cytoskeletal proteins expression in metastatic breast cancer cell line
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s):Breast cancer is an important leading cause of death from cancer. Stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression ...
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2-(2-(4-Benzoylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives: Synthesis, docking and acetylcholinesterase inhibitory evaluation as anti-alzheimer agents
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s): Alzheimer's disease (AD) as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. Therefore, administration ...
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Phytochemistry and pharmacology of Ferula persica Boiss.: A review
(Mashhad University of Medical Sciences, 2017-01-01)Ferula persica, is the well-known species of the genus Ferula in Iran and has two varieties: persica and latisecta. They have both been extensively used in traditional medicine for a ...
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Low-frequency vibration treatment of bone marrow stromal cells induces bone repair in vivo
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s):To study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. Materials and ...
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Evaluation of ethylcellulose and its pseudolatex (Surelease) in preparation of matrix pellets of theophylline using extrusion-spheronization
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s): This study evaluates the effect of substitution of microcrystalline cellulose (MCC) with ethylcellulose (EC) on mechanical and release characteristics of theophylline pellets. ...
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Effects of ellagic acid pretreatment on renal functions disturbances induced by global cerebral ischemic-reperfusion in rat
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s): Global cerebral ischemia-reperfusion (GCIR) causes disturbances in brain functions as well as other organs such as kidney. Our aim was to evaluate the protective effects of ellagic ...
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Cisplatin cytotoxicity is dependent on mitochondrial respiration in Saccharomyces cerevisiae
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s): To understand the role of mitochondrial respiration in cisplatin sensitivity, we have employed wild-type and mitochondrial DNA depleted Rho0 yeast cells. Materials ...
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Endurance training induces fiber type-specific revascularization in hindlimb skeletal muscles of rats with chronic heart failure
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s): Previous studies showed that skeletal muscle microcirculation was reduced in chronic heart failure. The aim of this study was to investigate the effects of endurance training on ...
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In vitro assesment of anti-inflammatory activities of coumarin and Indonesian cassia extract in RAW264.7 murine macrophage cell line
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s): Inflammation is an immune response toward injuries. Although inflammation is healing response, but in some condition it will lead to chronic disease such as rheumatoid arthritis, ...
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Time course of neuroprotection induced by in vivo normobaric hyperoxia preconditioning and angiogenesis factors
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s):Every year, a large number of people lose their lives due to stroke. Stroke is the second leading cause of death worldwide. Surprisingly, recent studies have shown that preconditioning ...
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Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s): Comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (AMT) on activated charcoal (AC) and ...
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Chronopharmacological effects of growth hormone on the executive function and oxidative stress response in rats
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s): to investigate the chronopharmacological effects of growth hormone on executive function and the oxidative stress response in rats. Materials and Methods: ...
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Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s): Neurotrophins (NTs) exert various effects on neuronal system. Growing evidence indicates that NTs are involved in the pathophysiology of neuropathic pain. However, the exact role of ...
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Antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury
(Mashhad University of Medical Sciences, 2017-01-01)Objective(s): To evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion–detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion ...



