Synthesis of dihydrofurans using biosynthesized CuO nanoparticles

Abstract

The preparation of <em>trans</em>-dihydrofurans has been achieved by a one-pot condensation reaction of 4-bromophenacyl bromide, aromatic aldehydes and 5,5-dimethyl-1,3-cyclohexanedione using biosynthesized CuO nanoparticles under reflux conditions in ethanol. CuO nanoparticles (CuO NPs) were prepared using extractof leaves of<em> Ajuga chamaecistus Subsp</em>.<em> Scoparia</em>. The key advantages of this process are the diastereoselective synthesis, reusability of the catalyst, low catalyst loading, excellent yields, short reaction times, simple workup and environmentally benign. Fully optimized structures of <em>trans</em> and <em>cis</em> dihydrofurans were obtained by B3LYP/6-31G(d,p) method. The structures of the prepared <em>trans</em>-2,3-dihydrofurans were fully characterized by ¹H and ¹³C NMR spectra, IR spectra, and elemental analysis.