Association of Matrix Metalloproteinase1-1607 1G>2G Polymorphism and Lung Cancer Risk: An Update by Meta-Analysis

Abstract

Objective: The association between matrix metalloproteinase1 (MMP1)-1607 1G>2G polymorphism and lung cancer<br />risk is still inconclusive and inconsistent. We conducted a meta-analysis to estimate the potential relationship between<br />MMP1-1607 1G>2G polymorphism and lung cancer risk. Methods: The comprehensive searches of the PubMed, Web<br />of Science, Medline, CBM, CNKI, Weipu, and Wanfang databases, published up to Nov 10, 2018. Statistical analyses<br />were performed with Review Manager 5.3 software. Results: A total of 14 relevant studies containing 6068 cases and<br />5860 controls were included in the study. The results indicated that MMP1-1607 1G>2G polymorphism was significantly<br />associated with increased lung cancer risk under four models: 2G vs. 1G model (pooled OR = 1.19, 95% CI = 1.05-1.34,<br />P < 0.0001); 2G/2G vs. 1G/1G (pooled OR = 1.34, 95% CI = 1.09-1.64, P = 0.003); 2G/2G vs. 1G/1G+1G/2G (pooled<br />OR = 1.26, 95% CI = 1.06-1.49, P < 0.0001); 2G/2G+1G/2G vs. 1G/1G (pooled OR = 1.21, 95% CI = 1.05-1.40, P<br />= 0.01). Subgroup analyses showed that there was a higher increase in smoking status under three models: 2G/2G<br />vs. 1G/1G (pooled OR = 2.07, 95% CI = 1.14-3.77, P = 0.02); 2G/2G vs. 1G/1G+1G/2G (pooled OR = 1.71, 95% CI<br />= 1.17-2.52, P = 0.006); 2G/2G+1G/2G vs. 1G/1G (pooled OR = 2.03, 95% CI = 1.14-3.62, P = 0.02). In addition,<br />subgroup analyses by ethnicity further identified the significant association in Asians. Non-smoking population and<br />ethnicity among Caucasian had no relationship with lung cancer susceptibility in four models. Conclusion: Our study<br />suggested that MMP1-1607 1G>2G polymorphism was a risk factor for developing lung cancer risk.