Application of dimeric ortho-palladated complex of 2-methoxyphenethylamine in the Heck coupling reaction

Abstract

The application of the [Pd{C₆H₃(CH₂CH₂NH₂)-4-OMe-5-<em>κ</em>²<em>-C,N</em>}(<em>μ</em>-Br)]₂ complex of 2-methoxyphenethylamine in the Heck coupling reaction was considered under both conventional and microwave irradiation conditions, and their results were compared. This complex is an efficient, stable and non-sensitive to air and moisture catalyst for the vinylation of substituted aryl halides with different electronic properties. The cross-coupled products were produced in good to excellent yields using a catalytic amount of this complex in <em>N</em>-methyl-2-pyrrolidone (NMP) at 130 °C. In comparison to conventional heating conditions, the reactions under microwave irradiation gave higher yields in shorter reaction times.