نمایش مختصر رکورد

dc.contributor.authorTavakkol Afshari, Zeinaben_US
dc.contributor.authorRahimi, Hamid Rezaen_US
dc.contributor.authorEhteshamfar, Seyed Mortezaen_US
dc.contributor.authorGanjali, Rashinen_US
dc.contributor.authorTara, Fatemehen_US
dc.contributor.authorShapouri Moghadam, Abbasen_US
dc.date.accessioned1399-07-09T07:49:27Zfa_IR
dc.date.accessioned2020-09-30T07:49:27Z
dc.date.available1399-07-09T07:49:27Zfa_IR
dc.date.available2020-09-30T07:49:27Z
dc.date.issued2016-12-01en_US
dc.date.issued1395-09-11fa_IR
dc.date.submitted2016-12-24en_US
dc.date.submitted1395-10-04fa_IR
dc.identifier.citationTavakkol Afshari, Zeinab, Rahimi, Hamid Reza, Ehteshamfar, Seyed Morteza, Ganjali, Rashin, Tara, Fatemeh, Shapouri Moghadam, Abbas. (2016). Tumor Necrosis Factor-α and Interleukin-1- β Polymorphisms in Pre-Eclampsia. Iranian Journal of Immunology, 13(4), 309-316.en_US
dc.identifier.issn1735-1383
dc.identifier.issn1735-367X
dc.identifier.urihttps://iji.sums.ac.ir/article_39282.html
dc.identifier.urihttps://iranjournals.nlai.ir/handle/123456789/329591
dc.description.abstractBackground: Pre-eclampsia is the most common critical condition during pregnancy. Plasma concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) increase in pregnant women with pre-eclampsia, compared to normal pregnant women. Objective: To investigate the polymorphisms of IL-1β (C+3954T), TNF-α (G- 308A), and (G-238A) in preeclemptic women northeastern Iran. Methods: This study was conducted on 153 preeclamptic women (case group) and 150 healthy pregnant women (control group), admitted to Ghaem and Imam Reza hospitals of Mashhad, Iran. IL-1β (C+3954T), TNF- α (G-238A) and TNF-α (G-308A) gene polymorphisms in the promoter region were screened by polymerase chain reaction. Data were analyzed, using SPSS version 16.0. Results: The mean age of the participants in the case and control groups was 28.2 ± 6.1 and 27.1 ± 6.3 years, respectively (P=0.68). The frequency of G-308A polymorphism was significantly higher in the case group, compared to the control group (p<0.001). However, no significant relationship was found between IL-1β genotype and pre-eclampsia (p=0.39). The frequency of TNF- α (G-238A) AA genotype was significantly higher in the case group, while GG genotype was less frequently detected in the case group, compared to the control group (p<0.001 for both genotypes). Moreover, the frequencies of AA genotypes of -238 TNF-α and G- 308A polymorphisms were significantly higher in the case group, compared to the control group (p<0.001). Conclusion: The significant correlation between inflammation promoting genotypes of TNF-α and Pre-eclampsia is noteworthy and provides evidence on the contribution of immune related genes in this disease.en_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherShiraz Institute for Cancer Researchen_US
dc.relation.ispartofIranian Journal of Immunologyen_US
dc.subjectGene Polymorphismen_US
dc.subjectInterleukin-1βen_US
dc.subjectPCR-RFLPen_US
dc.subjectPre-eclampsiaen_US
dc.subjectTumor necrosis Factor-αen_US
dc.titleTumor Necrosis Factor-α and Interleukin-1- β Polymorphisms in Pre-Eclampsiaen_US
dc.typeTexten_US
dc.typeOriginal Articleen_US
dc.contributor.departmentBu-Ali Research Institute, Department of Immunogenetics, Mashhad University of Medical Sciences, Mashhad, Iranen_US
dc.contributor.departmentDepartment of Advanced Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iranen_US
dc.contributor.departmentBu-Ali Research Institute, Department of Immunogenetics, Mashhad University of Medical Sciences, Mashhad, Iranen_US
dc.contributor.departmentBu-Ali Research Institute, Department of Immunogenetics, Mashhad University of Medical Sciences, Mashhad, Iranen_US
dc.contributor.departmentWomen's Health Research Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iranen_US
dc.contributor.departmentBu-Ali Research Institute, Department of Immunogenetics, Mashhad University of Medical Sciences, Mashhad, Iranen_US
dc.citation.volume13
dc.citation.issue4
dc.citation.spage309
dc.citation.epage316


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