نمایش مختصر رکورد

dc.contributor.authorFarshad, Shohrehen_US
dc.contributor.authorRasouli, Manoochehren_US
dc.contributor.authorJamshidzadeh, Akramen_US
dc.contributor.authorHosseinkhani, Aydaen_US
dc.contributor.authorJaponi, Azizen_US
dc.contributor.authorAlborzi, Abdolvahaben_US
dc.contributor.authorTaghavi, Alirezaen_US
dc.contributor.authorKazemi Asl, Hosseinen_US
dc.contributor.authorRanjbar, Rezaen_US
dc.date.accessioned1399-07-09T07:48:31Zfa_IR
dc.date.accessioned2020-09-30T07:48:31Z
dc.date.available1399-07-09T07:48:31Zfa_IR
dc.date.available2020-09-30T07:48:31Z
dc.date.issued2010-06-01en_US
dc.date.issued1389-03-11fa_IR
dc.date.submitted2016-08-06en_US
dc.date.submitted1395-05-16fa_IR
dc.identifier.citationFarshad, Shohreh, Rasouli, Manoochehr, Jamshidzadeh, Akram, Hosseinkhani, Ayda, Japoni, Aziz, Alborzi, Abdolvahab, Taghavi, Alireza, Kazemi Asl, Hossein, Ranjbar, Reza. (2010). IL-1β (+3953 C/T) and IL-8 (-251 A/T) Gene Polymorphisms in H. pylori Mediated Gastric Disorders. Iranian Journal of Immunology, 7(2), 96-108.en_US
dc.identifier.issn1735-1383
dc.identifier.issn1735-367X
dc.identifier.urihttps://iji.sums.ac.ir/article_17045.html
dc.identifier.urihttps://iranjournals.nlai.ir/handle/123456789/329290
dc.description.abstract<b>Background</b>: Previous studies imply that IL-1 and IL-8 gene variations may play a crucial role in the genetic predisposition to different gastric disorders upon H. pylori infection. <br/><b>Objective</b>: The aim of this study was to determine the potential association between the prevalence of certain polymorphic sites and the risk of gastric disorders in Iranian population. <br/><b>Methods</b>: One hundred and forty three unrelated individuals with different gastric disorders and 374 normal individuals with no gastric disorders and with a negative serology test for H. pylori (control group) were studied for the association between IL-1β (+3953 C/T) and IL-8 (-251 A/T) gene polymorphisms and H. pylorimediated gastritis and gastric ulcer. An analysis of genotype frequency for these genes was performed using RFLP-PCR. <br/><b>Results</b>: Based on the data obtained from culture and pathologic findings, the patients were classified into three subpopulations: H pylori+ non-ulcerative gastritis+, H. pylori+ ulcerative gastritis+ and H. pylori- non-ulcerative gastritis+. A significantly higher frequency of TT genotype (p=0.02) in IL-1β +3953 in H. pylori+ ulcerative gastritis+ was revealed compared to the control group. There were no significant differences among other subpopulations. No significant differences in allele and genotype frequencies of IL-8 (-251A/T) were found among the patients. <br/><b>Conclusion</b>: The data suggest that TT genotype in IL-1β +3953 may be a major contributing genetic risk factor for H. pylori induced gastric ulcer. Moreover, the role of other bacterial and host response factors, such as bacterial adherence peptides, host chemokines, and genes involved in gastric acid secretion, must be further investigated in different ethnic populations.en_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherShiraz Institute for Cancer Researchen_US
dc.relation.ispartofIranian Journal of Immunologyen_US
dc.subjectGastric Diseasesen_US
dc.subjectHelicobacter pylorien_US
dc.subjectIL-1βen_US
dc.subjectIL-8en_US
dc.subjectPolymorphismen_US
dc.titleIL-1β (+3953 C/T) and IL-8 (-251 A/T) Gene Polymorphisms in H. pylori Mediated Gastric Disordersen_US
dc.typeTexten_US
dc.typeOriginal Articleen_US
dc.contributor.departmentProf. Alborzi Clinical Microbiology Research Centeren_US
dc.contributor.departmentProf. Alborzi Clinical Microbiology Research Centeren_US
dc.contributor.departmentFaculty of Pharmacyen_US
dc.contributor.departmentFaculty of Pharmacyen_US
dc.contributor.departmentProf. Alborzi Clinical Microbiology Research Centeren_US
dc.contributor.departmentProf. Alborzi Clinical Microbiology Research Centeren_US
dc.contributor.departmentGastroenterohepatology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iranen_US
dc.contributor.departmentGastroenterohepatology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iranen_US
dc.contributor.departmentMolecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iranen_US
dc.citation.volume7
dc.citation.issue2
dc.citation.spage96
dc.citation.epage108


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