Goseki Grade and Tumour Location Influence Survival of Patients with Gastric Cancer

Abstract

<b>Background:</b> Owing to the variability of histopathological features and biological behaviour in gastriccarcinoma, a great number of categorisation methods such as classical histopathologic grading, Laurenclassification, the TNM staging system and the newly presented Goseki grading method are used by pathologistsand other scientists. In our study, we aimed to investigate whether Goseki grade and tumour location havean effects on survival of gastric cancer cases. Materials and <br/><b>Methods</b>: Eighty-four patients with gastricadenocarcinoma were covered in the investigation. The importance of Goseki grading system and tumour locationwere analysed in addition to the TNM staging and other conventional prognostic parameters. <br/><b>Results</b>: Themedian survival time in our patients was 35 months (minimum: 5, maximum: 116). According to our findings,there was no relation between survival and tumour size (p=0.192) or classical histological type (p=0.270). Incontrast, the Goseki grade and tumour location significantly correlated with survival (p=0.007 and p<0.001,respectively). Additionally, tumours of the intestinal type had a longer median survival time (60.0 months) thandiffuse tumours (24.0 months). <br/><b>Conclusions</b>: In addition to the TNM staging system, tumour location and theGoseki grading system may be used as significant prognostic parameters in patients with gastric cancer.