cardiac damage in left breast cancer patients

Abstract

<strong>Introduction </strong>:Today there is general awareness of the potential damage to the heart in left- sided (more than in rightsided) breast cancer radiotherapy.

<strong>Material & Method: </strong>Historical changes in tumor and heart doses are presented here along with the impact of different RT techniques and volumes. <strong>Results:</strong> Individual and pharmacological risk factors are also examined with respect to radiation damage. The biological mechanisms of harm are only partially understood, such as the radiobiology of heart damage due to the presence of various radiosensitive structures

and their topographic heterogeneity.

<strong>Conclusions: </strong>individual variability may expose patients to higher or lower risks of late

cardiac damage or death. Damage mechanisms and radiobiological characteristics in heart

irradiation are presented in relation to dosimetric and biological parameters.