KRT13, FAIM2 and CYP2W1 mRNA Expression in Oral Squamous Cell Carcinoma Patients with Risk Habits

Abstract

<b>Background:</b> Expression of KRT13, FAIM2 and CYP2W1 appears to be influenced by risk habits, thusexploring the associations of these genes in oral squamous cell cancer (OSCC) with risk habits, clinico-pathologicalparameters and patient survival may be beneficial in identifying relevant biomarkers with different oncogenicpathways. Materials and <br/><b>Methods</b>: cDNAs from 41 OSCC samples with and without risk habits were includedin this study. Quantitative real-time PCR was used to analyze KRT13, FAIM2 and CYP2W1 in OSCC. Thehousekeeping gene (GAPDH) was used as an endogenous control. <br/><b>Results</b>: Of the 41 OSCC samples, KRT13was down-regulated in 40 samples (97.6%), while FAIM2 and CYP2W1 were down-regulated in 61.0% and48.8%, respectively. Overall, there were no associations between KRT13, FAIM2 and CYP2W1 expression withrisk habits, selected socio-demographic and clinico-pathological parameters and patient survival. <br/><b>Conclusions</b>:Although this study was unable to show significance, there were some tendencies in the associations of KRT13,FAIM2 and CYP2W1 expression in OSCC with selected clinic-pathological parameters and survival.