Ubenimex capsule Improves General Performance and Chemotherapy related Toxicity in Advanced Gastric Cancer Cases
نوع فايل (MIME):PDF
Objective: To evaluate the effect of ubenimex capsule on general performance and chemotherapy relatedtoxicity in patients with advanced gastric cancer undergoing chemotherapy. Methods: Patients with advancedgastric cancer were randomly divided into two groups: with or without ubenimex. All received the followingregimen for 2 cycles: docetaxel 40mg/m2 intravenous infusion on days 1 and 8, cisplatin 15mg/m2 and tegafur600mg/m2 intravenous infusion from days 1 to 5. Oral ubenimex capsule at 30mg daily was continued for 8 weeksfrom the start of chemotherapy. Study targets included Karnofsky performance status (KPS), body weight,leukocytes, hemoglobin, variation of several immunologic index prior,during and after chemotherapy. Results:Sixty-three patients were recruited into this study, 32 randomly entered into the ubenimex capsule and 31 intothe control group. KPS score and body weight after chemotherapy were more stable in the treatment group(P Conclusion: Ubenimex capsule could improve general performance and reduce chemotherapy related toxicityin patients with advanced gastric cancer.
ناشرWest Asia Organization for Cancer Prevention (WAOCP)