Clinical Analysis of Stages of HBV Infection in 100 Cases of Lymphoma

Abstract

<br/><b>Objective</b>: HBV infection may cause damage to the immune system and induce lymphomas as a result.Some scholars have indicated that HBsAg(+) reflecting HBV infection may have a relationship with lymphomadevelopment. This study was designed to find out the specific stage of HBV infection which may be related tolymphoma. <br/><b>Methods</b>: HBV serum markers, including HBsAg, HBsAb, HBeAg, HBeAb, HBcAb were testedamong 100 lymphoma patients and 100 other patients who were diagnosed with non-lymphoma diseases in theFirst Hospital of Jilin University from 2010.1.1 to 2012.12.31. Three subgroups were established dependingon different combinations of HBV serum markers. Subgroup 1 was HBsAg(+) representing the early stage ofHBV infection. Subgroup 2 was HbsAb(+) representing convalescence and Subgroup 3 was “HbsAg and HbsAbnegative combined with other positive markers” representing the intermediate stage of HBV infection. Chisquare tests were used to compare the rates of three subgroups in lymphoma and control groups. <br/><b>Results</b>: Therates of Subgroup were 13% and 5% respectively, an association between HBsAg and lymphoma being found(P<0.05). There was no difference between rate of Subgroup 2 of lymphoma group (15%) and that of controlgroup (16%). In lymphoma group and control group , the rate of Subgroup 3 was different (12% vs 4%). Thisevidence was not specific to T cell lymphoma, B cell lymphoma or Hodgkin’s lymphoma. <br/><b>Conclusions</b>: Amongserum markers of HBV, the combination of serum markers representing the early stage and intermediate stageof HBV infection have a relationship with lymphoma. Convalescence from HBV infection appears to have norelationship with lymphoma.