Absence of Human Papillomavirus in Benign and Malignant Breast Tissue

Abstract

<span style="font-size: 14px;"><span style="text-align: justify;"><span style="font-family: 'times new roman';"><strong><span style="color: #0000ff;">Background & Objective:</span></strong></span></span></span><br /> <span style="font-size: 14px; text-align: justify; font-family: 'times new roman';"><span style="color: #000000;">Malignant breast tumors, which are one of the most important deadly cancers in women, like many other cancers, are proposed to be related to viruses etiologically. Proper management of breast carcinoma necessitates an identification of the etiological factors. </span></span><span style="font-size: 14px; text-align: justify; font-family: 'times new roman';"><span style="color: #000000;"><em>Human Papilomavirus </em></span></span><span style="font-size: 14px; text-align: justify; font-family: 'times new roman';"><span style="color: #000000;">is considered to have an etiological role in breast carcinoma. We carried out this study to find out if </span></span><span style="font-size: 14px; text-align: justify; font-family: 'times new roman';"><span style="color: #000000;"><em>Human Papilomavirus</em></span></span><span style="font-size: 14px; text-align: justify; font-family: 'times new roman';"><span style="color: #000000;">-DNA is present in the malignant and benign breast tissue in our patients.</span></span><br /> <span style="font-size: 14px;"><span style="text-align: justify;"><span style="font-family: 'times new roman';"><span style="color: #0000ff;"><strong>Methods:</strong></span></span></span></span><br /> <span style="font-size: 14px; text-align: justify; font-family: 'times new roman';"><span style="color: #000000;">Seventy five paraffin-embedded breast cancer tissues and 75 normal breast tissues and benign breast lesions were examined in this study (case-control) to look for </span></span><span style="font-size: 14px; text-align: justify; font-family: 'times new roman';"><span style="color: #000000;"><em>Human Papilomavirus</em></span></span><span style="font-size: 14px; text-align: justify; font-family: 'times new roman';"><span style="color: #000000;">-DNA employing Nested Polymerase Chain reaction. The tissues were examined over a period of ten years in the pathology department of the Pathobiology Laboratory Center of Tehran.</span></span><br /> <span style="font-size: 14px;"><span style="text-align: justify;"><span style="font-family: 'times new roman';"><strong><span style="color: #0000ff;">Result:</span></strong></span></span></span><br /> <span style="font-size: 14px; text-align: justify; font-family: 'times new roman';"><span style="color: #000000;">No </span></span><span style="font-size: 14px; text-align: justify; font-family: 'times new roman';"><span style="color: #000000;"><em>Human Papilomavirus</em></span></span><span style="font-size: 14px; text-align: justify; font-family: 'times new roman';"><span style="color: #000000;">-DNA was found in any of the malignant or control group specimens.</span></span><br /> <span style="font-size: 14px;"><span style="text-align: justify;"><span style="font-family: 'times new roman';"><strong><span style="color: #0000ff;">Conclusion:</span></strong></span></span></span><br /> <span style="text-align: justify; font-size: 14px;"><span style="font-family: 'times new roman';"><span style="color: #000000;">Our results showed no evidence of </span></span><span style="font-family: 'times new roman';"><span style="color: #000000;"><em>Human Papilomavirus </em></span></span><span style="font-family: 'times new roman';"><span style="color: #000000;">in cancerous and benign tissues, which is consistent with some other studies in English medical literature. More investigations using more specimens from different parts of the country are required to confirm the presence or absence of any connection between </span></span><span style="font-family: 'times new roman';"><span style="color: #000000;"><em>Human Papilomavirus </em></span></span></span><span style="text-align: justify; font-family: 'times new roman';"><span style="font-size: 16px;"><span style="color: #000000;"><span style="font-size: 14px;">and development of breast carcinoma in Iran.</span></span></span></span>