Effect of Low Level Laser Therapy on the Surgical Wound Healing in Hamster

Abstract

<em>Background and Objectives</em><em>:</em> Accelerating wound healing is a very important factor for patients to return to ordinary life. Laser seems to have positive effect on cutaneous wound healing. This study aimed to investigate the effect of red light laser 630 nm on cutaneous surgical wound in hamster and to compare outcomes such as angiogenesis, number of fibroblasts and collagen formation in intervention and control group. <em>Material</em><em>s and Methods:</em> This experimental study carried out with collaboration of Qazvin University of Medical Sciences with Mehregan Pet Clinic in winter of 2009. Thirty suri hamsters were randomly allocated in two groups and four parallel wounds were made on their backs. The intervention group was radiated with red-light laser 630 nm. After 2,5,10 and 14 days, skin biopsy were obtained and number of blood vessels, fibroblast and collagen production were compared with the control group. Data were analyzed using independent sample student <em>t</em> test using SPSS version 10 and <em>P </em>value less than 0.05 was considered significant. <em>Result:</em> Evaluation of wounds in experimental and control groups showed significantly increased number of vessels and fibroblasts as well as collagen production in laser radiating group (<em>P</em><0.05). <em>Conclusion:</em> Laser therapy (630 nm) can accelerate wound healing in comparison with control group.