Correlation of ER, PR, HER- 2 and P53 Immunoreactions with Clinico-Pathological Features in Breast Cancer

Abstract

Background and Objectives: The most prevalent malignancy among women is known to be breast cancer (BC). Several factors contribute to determining tumor prognosis and treatment strategies. In this study, the frequency and relevance of these factors are discussed. Materials and Methods: This cross-sectional study was carried out on 214 patients with BC, who referred to the Cancer Institute of Imam Hospital complex, Tehran, Iran in 2010 and 2011. The data about biomarkers (ER, PR, P53, HER-2) status and clinic pathologic features were extracted from patients files. Results: Invasive ductal carcinoma (90.7%) was the most common pathology of BC. The frequency of estrogen receptor (ER), progesterone receptor (PR), P53 and HER2 was estimated as 63.6%, 58.9%, 37.4% and 21.9% respectively. None of these markers had significant relationship with age, tumor size, tumor pathology, vascular invasion, calcification, nipple invasion, benign component, skin invasion and mitosis. Between low grade histology of tumor and ER, PR significant positive relationship was found (<em>P</em>=0.001). Lymph node involvement was positively associated with P53 expression. A positive relationship found between ER and PR (<em>P</em>=0.001). Both P53 and HER-2 inversely correlate with ER, PR (<em>P</em>=0.001). HER2 and P53 had no significant relationship. Conclusion: We found a significantly higher PR⁽⁺⁾, ER⁽⁺⁾ expression in low grade tumors. Although P53 and HER2 expressions were not found to be correlated with tumor grade, P53 expression was associated with poorer prognosis due to higher lymph node involvement and perineural invasion.