The Effect of Two Different Doses of Atorvastatin on Lipoprotein-A on Patients with Acute Coronary Syndrome

Abstract

Background and Objectives: Lipoprotein-a potentially represents a useful tool for risk stratification in cardiovascular accidents. The aim of this study was to evaluate the atorvastatin effect on serum lipid profile & lipoprotein A. Material & Methods: In 2009, 405 patients with acute coronary syndrome randomly were divided into 2 groups, taking 20 & 40 mg atorvastatin daily for 3 months. Lipid profile & lipoprotein-A serum levels were checked at the beginning of the study and also one and three months later. Results: There was no statistical difference between the two groups in all measurements except in patients with unstable angina. The difference lay in the change of LP-a level after one month (<em>P</em>=0.045) and in apo-A level in all patients in the second and the third measurements compared with the first one (<em>P</em>=0.001 & <em>P</em>=0.002). Discussion: It appears that the two doses (20mg and 40mg) of atorvastatin have a reduction effect on lipoprotein-A and serum lipid levels, but no difference is seen in the level of reduction. The 40 mg atorvastatin leaves more effects on reduction of apo-A than on the 20 mg after one and three months.