Epstein-Barr Virus and Human Herpesvirus 8 in Idiopathic Pulmonary Fibrosis

Abstract

<span style="font-size: 14px;"><span style="font-family: times new roman;"><span style="color: #0000ff;"><strong>Background & Objective:</strong></span></span></span><br /><span style="font-family: times new roman;"><span style="font-size: 14px;">Idiopathic pulmonary fibrosis (IPF) is a chronic and uniformly fatal interstitial lung disease with incompletely understood pathogenesis. Several studies have given the evidence for and against viral cofactors in the pathogenesis of Idiopathic pulmonary fibrosis. In this study <em>Epstein-Bar Virus</em> (EBV) and <em>Human</em> <em>Herpesvirus 8</em> (HHV-8) have been studied for a possible role in the pathogenesis of IPF.</span></span><br /><span style="font-size: 14px;"><span style="font-family: times new roman;"><span style="color: #0000cd;"><strong>Methods:</strong></span></span></span><br /><span style="font-family: times new roman;"><span style="font-size: 14px;">Polymerase chain reaction (PCR) was employed for the detection of EBV and HHV-8 in 58 formalin-fixed paraffin-embedded lung tissue specimens (29 controls and 29 IPF specimens).</span></span><br /><span style="font-size: 14px;"><span style="font-family: times new roman;"><span style="color: #0000cd;"><strong>Results:</strong></span></span></span><br /><span style="font-family: times new roman;"><span style="font-size: 14px;">EBV DNA was present in the lung tissue of 6 out of 29 (20.7%) IPF specimens compared with 1 out of 29 (3.4%) controls (<em>P</em>=0.102). The HHV-8 gene was identified in 3 out of 29 (10.3%) cases of IPF specimens. The control group showed no evidence of HHV-8 gene (<em>P</em>=0.227).</span></span><br /><span style="font-size: 14px;"><span style="font-family: times new roman;"><span style="color: #0000cd;"><strong>Conclusion:</strong></span></span></span><br /><span style="font-family: times new roman;"><span style="font-size: 14px;">Although multiple studies are strongly suggestive of a role for EBV and HHV-8 in the development of IPF, there was no statistically significant difference in the prevalence of EBV and HHV-8 DNA in the IPF specimens and controls in this study.</span></span>