Clinicopathological Features of Colon Adenocarcinoma in Qazvin, Iran: A 16 Year Study

Abstract

<b>Background:</b> Colorectal cancer (CRC) was the fourth most commonly diagnosed cancer in Iran between2000 and 2009, with adenocarcinoma (AC) as the most common histological type. Demographic, topographicand histological variables are important in the epidemiology and biology of cancer. The aim of this study was toinvestigate clinicopathological features of colon adenocarcinomas in Qazvin, Iran. Materials and <br/><b>Methods</b>: Witha retrospective design, patient records of two pathology wards from March 1997 to March 2013 were studiedwith regard to anatomical location and histological classification. A broader anatomical grouping was also usedincluding distal vs proximal regions and right sided vs left sided tumors. Data were analyzed using T-test andchi-square test. <br/><b>Results</b>: 118 (50.9%) male and 114 (49.1%) female patients were included in the study. Mean agewas 57.3±14.7 years, with 29.2% under 50 years. There was no significant gender difference for age at diagnosis.The rectum (56%) and sigmoid colon (25%) were the most frequent anatomical locations. Proximal casesaccounted for 18.6% in males and 8.8% in females (p=0.02). AC was more prevalent than other usual types inyounger patients. The proportion of proximal cancer was 1.7% in first eight years of the study period vs 12.1%in the second one (p=0.005). A similar trend was also seen in right sided colon cancers (p=0.018). <br/><b>Conclusions</b>:Young people are also at risk for the cancer with poor prognosis. Screening programs and weight loss in obeseindividuals can reduce incidence and complications of CRC.