Cytogenetic and Genetic Mutation Features of de novo Acute Myeloid Leukemia in Elderly Chinese Patients

Abstract

<br/><b>Objectives</b>: The present study aimed to examine the cytogenetic and genetic mutation features of acutemyeloid leukemia (AML) in elderly Chinese patients. <br/><b>Methods</b>: A retrospective analysis of cytogenetics andgenetic mutations was performed in 113 cases (age range 50-82 years) with de novo AML. <br/><b>Results</b>: The mostfrequent cytogenetic abnormality was t (15;17) (q22;q21), detected in 10.0% (n = 9) of successfully analyzedcases, followed by t (8;21) (q22;q22) in 8.89% (n = 8), and complex karyotypes in 5.56% (n = 5). Those withcomplex karyotypes included 4 cases (4.44%) of monosomal karyotypes. The frequencies of NPM1, FLT3-ITD,c-kit, and CEBPA mutations were 27.4% (31/113), 14.5% (16/110), 5.88% (6/102), and 23.3% (7/30), respectively.The complete remission rates of patients in low, intermediate, and high risk groups were 37.5%, 48.6%, and33.3%, respectively (χ2 = 0.704, P = 0.703) based on risk stratification. <br/><b>Conclusion</b>: Cytogenetics and geneticmutations alone may not be sufficient to evaluate the prognoses of elderly AML patients. The search for a novelmodel that would enable a more comprehensive evaluation of this population is therefore imperative.