Efficacy of Clobetasol, Ketoconazole and Amitryptiline Mouthwash on Oral Lichen Planus

Abstract

Oral Lichen Planus (OLP) is a chronic inflammatory disease of oral mucosa, with an immunological origin. Atrophic/erosive OLP needs appropriate treatment, due to the pain and malignancy potential. Topical corticosteroids are the most effective drug therapy and mouthwashes are more effective topical dosage forms for this purpose. However, at present there are no corticosteroid mouthwashes available in Iran. In this study, the efficacy of a new mouthwash containing clobetasol, ketoconasole and amitriptyline was evaluated in comparison to the common treatment. In this double blind randomized clinical trial study, 50 patients who had inclusion criteria were grouped randomly, with no difference in demographic data. The experimental group was treated using 5ml of mouthwash four times a day for 5 min, while the control group was treated by dexamethasone tablet, nystatin drop and diphenhydramine syrup. Severity of the lesions and pain were followed as the chief complain and recorded in the initial, 1, 2, 4, 8 and 12 weeks intervals. All the collected data were analyzed with the Chi-Square, Mann-Whitney, student T-test and Mantel-Cox statistical tests, using the SPSS version 13 softwares. There were significant differences in the pain reduction in the 1st (P