Formulation and In Vitro Evaluation of Silver Sulfadiazine Spray

Abstract

In order to improve local therapeutic techniques for the massively burnt patients and to minimize the pain associated with dressing change, the concept of topical film was utilized to formulate a topical antimicrobial spray. The commonly used topical antimicrobial silver sulfadiazine spray was formulated as a new drug delivery system. The release of therapeutic agents in vitro from medicated spray formulation was compared with that of the corresponding cream bases, utilizing a modified agar diffusion method. When using Pseudomonas aeroginosa as the test bacteria, silver sulfadiazine was found to produce a significantly larger zones of inhibition when used as the spray formulation instead of the cream form. Silver sulfadiazine spray, left in place for up to one day, appears to be as effective as the twice-daily cleansing and application of silver sulfadiazine cream. Also the periodic stability study of silver sulfadiazine in spray form, which was carried out using TLC, HPLC and particle size analyser methods, showed no significant degradation and crystal growth of active ingredient in the spray formulation after one year.