Among Recent advances in the identification of anti-inflammation agents, anti-cytokines (like Interleukin-1), related to p38 MAPK families play an important role; Here in we designed new effective and low toxic anti-cytokine ...

AIDS, as a lethal disease, is caused by infection with the HIV virus that affects millions of people. Three essential enzymes should be encoded for replication of HIV virus: protease, integrase and reverse transcriptase ...

Stroke was the second most frequent cause of death after coronary artery disease. The purpose of this study was to evaluate the effects of L-carnitine and Intralipid Fat emulsion alone and in combination in patients with ...

The development of a losartan potassium patch for the treatment of hypertension established that a combination of hydrophobic and hydrophilic polymers, using as a plasticizer citroflex and succinic acid as a cohesion ...

Prolonged epileptic seizures are the cause of neuronal death and brain damage. Lesions in different regions of the brain can lead to memory loss and cognitive disorders. It is therefore essential to seek out new neuroprotective ...

Discrete choice experiments (DCES) as a stated preference method have used increasingly todetermine preferences attached to some attributes associated to health. Although, the validity ofthis type of studies comprehensively ...

Atropa komarovii generates tropane alkaloids and three other compounds such as hyoscyamine. Racemate atropine and scopolamine (hyoscine) are the main alkaloids that have anticholinergic, antispasmodic and sedative agents. ...

In the present study, we investigated the effects of noscapine (0.5-2 µM), an alkaloid from the opium poppy(Papaver somniferum), on primary murine cortical neurons exposed to 60 min oxygen–glucose deprivation (OGD) in the ...

Although hydroxyurea is one of the most widely used drugs in treating breast cancer, the use of it leads to some side effects. Hence, in order to reduce complications of treatment and increase its efficiency, drug delivery ...

Since the biopharmaceutical quality of generic drug formulations depends on the quality of the reference products and also information about the in-vitro release performance of drugs under different conditions is scarce ...

Aims: In order to expand the application of Fe3O4@SiO2-SnCl4 in the synthesis of heterocyclic compounds, in this study, we wish to report the use of one-pot three component synthesis of pyrimido[4,5-b]quinolone derivatives ...

Sclareol is an organic compound with potential anti-tumor effects against various cancer types. However, its precise molecular mechanism in suppression of tumor growth has not been fully elucidated. In the present study ...

Otostegia fruticosa is traditionally used to treat tonsillitis, stomach ache, asthma, arthritis, and febrile illness in different parts of Ethiopia and other countries. In this experiment 70% ethanolic crude extract and ...

One of the main genotoxic drugs used in bladder cancer chemotherapy is cisplatin. While it is applied in most types of cancers, resistance to cisplatin is wildly common. In order to overcome drug resistance, it is necessary ...

Scorpion venoms contain potentially useful pharmacological agents. Several studies demonstrate that the venoms of some scorpions induce apoptosis and inhibit the growth of cancer cells; therefore, they have been investigated ...

Most of drugs are administered orally and they must be absorbed from gastrointestinal tract for systemic effect. Generally drug molecules be dissolved in GI fluids before absorption. Solubility and permeability of drugs ...

Recently, Wuhan, China became the epicenter for the outbreak of novel coronavirus pneumonia (COVID-19). No specific agents are available for treating COVID-19 while some agents such as antivirals, chloroquine, and ...

COVID-19 is currently causing concern in the medical community as the virus is spreadingaround the world. It has a heavy global burden, particularly in low-income countries. The clinicalspectrum of COVID-19 pneumonia ranges ...

An efficient gene delivery system has some critical factors that enhance the efficiency of nanocarrier. These factors are low production cost, high bioavailability, high encapsulation efficiency, controllable release, and ...

Determination of mirtazapine during psychopharmacotherapy in biological fluids is essential to achieve successful therapy, to avoid toxicity related to drug interactions, genetic variability and poor compliance. A new, ...