• Logic of Selecting Suitable Dissolution Parameters in New Drug Formulations Based on A BCS Approach 

  Medina, Jose Raul؛ Arregui, Edgar؛ Aranda, Edson؛ Moreno-Rocha, Alfonso؛ Hurtado, Marcela؛ Jung-Cook, Helgi؛ Helmy, Sally (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Since the biopharmaceutical quality of generic drug formulations depends on the quality of the reference products and also information about the in-vitro release performance of drugs under different conditions is scarce ...

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• STAT3-mediated apoptotic-enhancing function of sclareol against breast cancer cells and cell sensitization to cyclophosphamide 

  Afshari, Havva؛ Nourbakhsh, Mitra؛ Salehi, Niloufar؛ Mahboubi_Rabbani, Mohammad؛ Zarghi, Afshin؛ Noori, Shokoofe (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Sclareol is an organic compound with potential anti-tumor effects against various cancer types. However, its precise molecular mechanism in suppression of tumor growth has not been fully elucidated. In the present study ...

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• Noncompetitive inhibition of bovine liver catalase by lawsone: Kinetics, binding mechanism and in silico modeling approaches 

  Khataee, Simin؛ Dehghan, Gholamreza؛ Rashtbari, Samaneh؛ Dastmalchi, Siavoush؛ Iranshahi, Mehrdad (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Lawsone (2-hydroxy-1,4-naphtoquinone; LAW), as a naphthoquinone derivative, is the biologically active component of Henna leaves. In this study, the structural and functional effects of LAW on bovine liver catalase (BLC), ...

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• Isolation, purification and antioxidant activity of the polysaccharides from Chinese truffle<i> Tuber sinense</i> 

  Liu, Yanling؛ Chen, Xiaoyan؛ Jiang, Wen-wen؛ Liu, Yanling؛ Fang, Chunjuan (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  The content of polysaccharides in Tuber sinense was investigated by isolation and purification, followed with the further antioxidant studies in total reducing capacity and radical scavenging activities. The crude extract ...

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• Antioxidant Activity and Hemocompatibility Study of Quercetin Loaded Plga Nanoparticles 

  Derman, Serap؛ Uzunoglu, Deniz؛ ACAR, Tayfun؛ Ozbek Arasoglu, Tulin؛ Ucak, Samet؛ Ozalp, Veli؛ Mansuroglu, Banu (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Quercetin (QU) is an important flavonoid compound presenting lots of biological activities, but its application has been limited due to its low aqueous solubility and instability. In this study, in which conducted to improve ...

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• Development of a sensitive and rapid method for determination of acrylamide in bread by LC-MS/MS and analysis of real samples in Iran 

  Eslamizad, Samira؛ Kobarfard, Farzad؛ Tabib, Kimia؛ Yazdanpanah, Hassan؛ Salamzadeh, Jamshid (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  A new sample preparation procedure and a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method were developed for the quantitative analysis of acrylamide in bread. The method is based on sample extraction in ...

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• Noscapine Modulates Neuronal Response to Oxygen-glucose Deprivation/Reperfusion Injury Via Activation of Sigma-1 Receptor in Primary Cortical Cultures 

  Vahabzadeh, Gelareh؛ Rahbar-Roshandel, Nahid؛ Ebrahimi, Soltan-Ahmad (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  In the present study, we investigated the effects of noscapine (0.5-2 µM), an alkaloid from the opium poppy(Papaver somniferum), on primary murine cortical neurons exposed to 60 min oxygen–glucose deprivation (OGD) in the ...

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• A Preliminary Study of NER and MMR Pathways Involved in Chemotherapy Response in Bladder Transitional Cell Carcinoma: Impact on progression-free survival 

  Montazeri, Vahideh؛ Ghahremani, Mohammad Hossein؛ Montazeri, Hamed؛ Hasanzad, Mandana؛ Safavi, Majid؛ Ayati, Mohsan؛ Chehrazi, Mohammad؛ Arefi moghaddam, Baharak؛ Ostad, Seyed Naser (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  One of the main genotoxic drugs used in bladder cancer chemotherapy is cisplatin. While it is applied in most types of cancers, resistance to cisplatin is wildly common. In order to overcome drug resistance, it is necessary ...

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• Preparation, optimization and characterization of chitosan-coated for solubility enhancement of Furosemide: A model BCS IV drug 

  Moslehi, Mohammad؛ Mortazavi, Seyed Alireza؛ Azadi, Amir؛ Fateh, Samaneh؛ Hamidi, Mehrdad؛ Foroutan, Mohsen (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Most of drugs are administered orally and they must be absorbed from gastrointestinal tract for systemic effect. Generally drug molecules be dissolved in GI fluids before absorption. Solubility and permeability of drugs ...

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• Acetone Fraction of the Red Marine Alga <i>Laurencia Papillosa </I> Reduces the Expression of Bcl-2 Anti-apoptotic Marker and Flotillin-2 Lipid Raft Marker in MCF-7 Breast Cancer Cells 

  Elia, Josiane؛ Petit, Karina؛ Huvelin, Jean-Michel؛ Tannoury, Mona؛ Diab-Assaf, Mona؛ Carbonnelle, Delphine؛ Nazih, Hassan (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Marine macroalgae have attracted much attention in recent years as a valuable source of bioactive metabolites. The cytotoxic potential of the Laurencia papillosa red alga collected from the Lebanese coast has been investigated ...

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• Therapeutic Potential of Nanoparticle-loaded Hydroxyurea on Proliferation of Human Breast Adenocarcinoma Cell Line 

  azemati, Fateme؛ Jalali kondori, Bahman؛ Sheikhian, Ali (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Although hydroxyurea is one of the most widely used drugs in treating breast cancer, the use of it leads to some side effects. Hence, in order to reduce complications of treatment and increase its efficiency, drug delivery ...

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• Chemical Composition, Antioxidant, Genotoxique and Antigenotoxic Potentials of <I>Phlomis Bovei</I> De Noé Aerial Parts 

  Zaabat, Nabila؛ Hay - de Bettignies, Anne-emmanuelle؛ Michalet, Serge؛ Skandrani, Inès؛ Chekir-Ghedira, Leila؛ Dijoux-Francaa, Marie-Geneviève؛ Akkal, salah (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  In the present work, chemical investigation of the aerial parts of Phlomis bovei de Noé an endemic species from Algeria, led to the isolation and identification of seven known compounds including five flavones glycosides: ...

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• Improvement of Ocular Efficacy of Levofloxacin by Bioadhesive Chitosan Coated PLGA Nanoparticles: Box-Behnken Design, <I>In-vitro</I> Characterization, Antibacterial Evaluation and Scintigraphy Study 

  zafar, Ameeduzzafar؛ Khan, Nazia؛ Alruwaili, Nabil؛ Bukhari, Syed Nasir؛ Alsuwayt, Bader؛ Afzal, Muhammad؛ Akhtar, Sana؛ Yasir, Mohd؛ Elmowafy, Mohammed؛ Shalaby, khaled؛ Ali, Asgar (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Conjunctivitis is considered as a common infection of ocular surfaces. Eye drop is most commonly used for treatment of conjunctivitis, but has some drawback like 95% drug eliminated after administration. Administration of ...

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• Attributes Development for Pharmaceutical Subsidization: A Qualitative Study 

  afsharmanesh, gita؛ Mehralian, Gholamhossein؛ Peiravian, Farzad (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Discrete choice experiments (DCES) as a stated preference method have used increasingly todetermine preferences attached to some attributes associated to health. Although, the validity ofthis type of studies comprehensively ...

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• Docking, Synthesis and Evaluation of the Antifungal Activity of Pyrimido[4,5-b]Quinolins 

  Araqi, Reza؛ Mirjalili, Bi Bi Fatemeh؛ zamani, leila؛ Mirjalili, Bi Bi Fatemeh؛ Zomorodian, Kamiar؛ Faghih, Zeinab؛ Arabi, Hamhdreza (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Aims: In order to expand the application of Fe3O4@SiO2-SnCl4 in the synthesis of heterocyclic compounds, in this study, we wish to report the use of one-pot three component synthesis of pyrimido[4,5-b]quinolone derivatives ...

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• Analgesic, Anti-inflammatory and <I>In-vitro</I> Hyaluronidase Inhibitory Properties of the Leaf Extract and solvent fractions of <I>Otostegia fruticosa </I> (Forssk.) Schweinf. ex Penzig. 

  Bahta, Tiegsti؛ Karim, Aman؛ P, GOMATHI؛ Gebremedhin, Gereziher؛ ur rehman, Najeeb؛ Bitew, Helen؛ Hagazi, Kalay (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Otostegia fruticosa is traditionally used to treat tonsillitis, stomach ache, asthma, arthritis, and febrile illness in different parts of Ethiopia and other countries. In this experiment 70% ethanolic crude extract and ...

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• <i>In-vitro </i>Study of <I>Hottentotta Schach</i> Crude Venom Anticancer Effects on MCF-7 and Vero Cell Lines 

  Dezianian, Saeed؛ zargan, jamil؛ Goudarzi, Hamid Reza؛ zargan, jamil؛ Mousavi, Mohsen؛ keshavarz Alikhani, hani؛ Johari, Behrooz (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Scorpion venoms contain potentially useful pharmacological agents. Several studies demonstrate that the venoms of some scorpions induce apoptosis and inhibit the growth of cancer cells; therefore, they have been investigated ...

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• Design and Synthesis of Novel 1-Hydroxy-2,4,5-triaryl Imidazole Derivatives as Anti-Cytokine Agent 

  haghighijoo, zahra؛ Firuzi, Omidreza؛ meili, savis؛ Edraki, Najmeh؛ Khoshneviszadeh, mehdi؛ miri, ramin (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  Among Recent advances in the identification of anti-inflammation agents, anti-cytokines (like Interleukin-1), related to p38 MAPK families play an important role; Here in we designed new effective and low toxic anti-cytokine ...

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• Design and Evaluation of Losartan Transdermal Patch by Using Solid Microneedles as A Physical Permeation Enhancer 

  Anguiano Almazan, Ericka؛ Serrano Castañeda, Pablo؛ Diaz Torres, Roberto؛ Escobar-Chavez, Jose (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  The development of a losartan potassium patch for the treatment of hypertension established that a combination of hydrophobic and hydrophilic polymers, using as a plasticizer citroflex and succinic acid as a cohesion ...

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• Comprehensive Evaluation of Gene Expression in Negative and Positive Trigger-based Targeting Niosomes in HEK-293 Cell Line 

  barani, mahmood؛ Torkzadeh-Mahani, Masoud؛ Mirzaei, Mohammad؛ Nematollahi, Mohammad Hadi (School of Pharmacy, Shahid Beheshti University of Medical Sciences, 2020-02-01)

  An efficient gene delivery system has some critical factors that enhance the efficiency of nanocarrier. These factors are low production cost, high bioavailability, high encapsulation efficiency, controllable release, and ...

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