Impact of Cyclin D1 and Heterogeneous Nuclear Ribonucleoprotein-K (HnRNP-K) on Urinary Bladder Carcinogenesis
(ندگان)پدیدآور
Aboushousha, TarekHammam, OlfatHelal, NohaEl Dahshan, Samirنوع مدرک
TextResearch Articles
زبان مدرک
Englishچکیده
Objective: This study aimed to investigate the expression of cyclin D1 and hnRNP-K in relation to the pathologicalfindings in bladder cancer including the type, grade, muscle invasion and bilharzial association. Methods: We studiedthe immunoexpression; as regard the percentage, intensity and score of both cyclin D1 and hnRNP-K in different bladderlesions including 10 cases of cystitis; 10 cases of carcinoma insitu (CIS), 20 cases of Squamous cell carcinoma (SCC)and 66 cases of urothelial carcinoma (UC). Results: High expression of cyclin D1 was found in UC compared to othergroups (p(pand non-papillary tumors compared to their counterparts (pexpression of hnRNP-K percent (pcontribution of cyclin D1 and hnRNP-K expression in the initiation and progression of urinary bladder carcinoma,so, both of them can be used in predicting progression of urinary bladder carcinoma and to differentiate between UCand SCC in high grade tumors. The possible role of both markers in immunotherapy deserves supplementary studies.
کلید واژگان
bladder cancerbilharziasis
Cyclin D1
hnRNP-K
immunohistochemistry
Pathology
شماره نشریه
2تاریخ نشر
2018-02-011396-11-12
ناشر
West Asia Organization for Cancer Prevention (WAOCP)سازمان پدید آورنده
Pathology Departments,Theodor Bilharz Research Institute, Cairo, Egypt.Pathology Departments,Theodor Bilharz Research Institute, Cairo, Egypt.
Pathology Departments,Theodor Bilharz Research Institute, Cairo, Egypt.
Urology Departments, Theodor Bilharz Research Institute, Cairo, Egypt.
شاپا
1513-73682476-762X