A new approach to develop a vaccine against capripox infection in sheep and goats using a new strain of sheep pox virus in Iran

Abstract

This report describes the preparation of a safe and immunogenic single vaccine against capripox disease in sheep and goats using two different types of cells (primary lamb kidney and vero, a bovine turbinate cell line). This used the 0240 pox strain isolated from sheep during an outbreak. The prepared vaccine was administered subcutaneously and induced complete protection against an experimental sheep and goat pox challenge virus. For the final evaluation, the efficacy of the prepared vaccine was used in a field trial under the supervision of veterinary clinicians. This vaccine was proved to be more efficacious than the routine vaccines that are currently produced.