The role of the histaminergic system on the inhibitory effect of ghrelin on feed intake in broiler chickens

Abstract

This study was conducted to investigate the possible involvement of the histaminergic system in themediation of ghrelin-induced feeding behavior in broiler chickens. In the trial 1, the effect ofintracerebroventricular (ICV) injection of ghrelin on feed intake was examined in 3-h feed-deprived broilerchickens. In the trials 2 and 3, the chickens were received ICV chlorpheniramine (an H1 receptor antagonist)and cimetidine (an H2 receptor antagonist) prior to ghrelin injection, respectively. Cumulative feed intakewas measured at 3-h post injections. Infusion of ghrelin (0.3, 0.6 and 1.2 nmol) decreased feed intake dosedependently (P