Clinicopathological Features and Localization of Gastric Cancers and their Effects on Survival in Turkey

Abstract

<b>Background:</b> This study was designed to examine changing trends in localization of gastric cancer in Turkeyin recent years. Materials and <br/><b>Methods</b>: A total of 796 adult patients with newly diagnosed, histologicallyproven adenocarcinomas, treated and followed up at our oncology center between 2000-2011, were examinedretrospectively. In all cases tumor localization were identified and recorded with clinicopathological features.<br/><b>Results</b>: The median age was 58 with a range between 22-90 for the 552 men and 244 women. Median followup was 12 months (1-276) and median overall survival was also 12 months (11.5-12.4). There was a trend for achange in tumor localization from distal to proximal. Survival of patients was low with advanced T and N stagetumours. Positive surgical margins, lymphovascular invasion, perineural invasion, cardioesophageal localizationwere predisposition factors for metastatic disease in gastric cancer. There was no relation between age or sexand histopathological type of gastric cancer. <br/><b>Conclusions</b>: There is a trend in our country for a change in gastrictumour localization from distal to proximal, with clear significance for treatment choices.