Clinically, elevated cancer antigen 125 (CA-125) in blood predicts tumor burden in a woman’s body, especiallyin the ovary, but cannot differentiate between malignant or benign. We here used intensive modern proteomicapproaches ...

Background: Most of the epidemiology studies on the effects of sun exposure and prostate cancer wereconducted among the temperate countries of North America and Europe. Little is known about the influenceon Asian ...

Osteosarcoma, the most common primary mesenchymal malignant tumor, usually has bad prognosis inman, with cancer stem-like cells (CSCs) considered to play a critical role in tumorigenesis and drug-resistance.It is known ...

Background: For cervical cancer the epidemiological profile is poorly known in Morocco and no data isavailable concerning the direct medical costs. The purpose of this work is to estimate the direct cost of ...

The aim of this study was to investigate the possible relationship between antioxidant vitamin levels andmalignant pleural mesothelioma (MPM). For this purpose, we measured the serum levels of 4 antioxidantvitamins, ...

Aim: The significance of the mucinous adenocarcinoma in TNM staging and prognosis for colorectal tumorpatients is still controversial. The aim was to provide a meta-analysis for TNM staging and prognostic featuresof ...

Background: Many studies have focused on possible associations between the glutathione S-transferase M1 (GSTM1) null genotype and risk of renal cell carcinoma (RCC), but the impact remains unclear owing toobvious ...

Aim: To evaluate the association of glutathione S-transferases gene polymorphisms with the risk of gastriccancer, with reference to smoking and Helicobacter pylori infection. Methods: We conducted a 1:1 matched ...

Background and objectives: Chromosomal abnormalities play an important role in genesis of acute lymphoblastic leukemia (ALL) and have prognostic implications. Five major risk stratifying fusion genes in ALL are BCR-ABL, ...

Background: Though open surgical biopsy is the procedure of choice for the diagnosis of bone tumors,many disadvantages are associated with this approach. The present study was undertaken to evaluate the roleof fine ...

Human epidermal growth factor receptor 2 (HER2) is a member of the epidermal growth factor receptorfamily of receptor tyrosine kinases that plays important roles in all processes of cell development. Theiroverexpression ...

Background: Several potential risk factors have been identified for diffuse large B-cell lymphoma (DLBCL);however, epidemiological studies investigating the association between these risk factors and DLBCL haveyielded ...

Backgrounds: To investigate the inhibiting effects of multi-target anti-microRNA antisense oligonucleotide(MTg-AMOs) on proliferation and migration of human gastric cancer cells. Methods: Single anti-microRNAantisense ...

Purpose : This study was performed to assess whether the weight status is associated with screeningrates of breast and cervical cancer in Korean women. Methods: Study participants included women agedbetween 30 ...

Objective: To evaluate the efficacy and safety of whole brain radiotherapy (WBRT) plus chemotherapyversus WBRT alone for treating brain metastases (BM) from lung cancer by performing a meta-analysis basedon ...

Hepatocellular carcinoma (HCC), the most common primary hepatic tumor, is highly prevalent in the Asia-Pacific region, including Thailand. Many genetic and epigenetic alterations in HCC have been elucidated. Theaim of this ...

HMGN5 is a typical member of the HMGN (high mobility group nucleosome-binding protein) family whichmay function as a nucleosomal binding and transcriptional activating protein. Overexpression of HMGN5 hasbeen observed in ...

Objective: The aim of this study was to investigate possible mechanisms of LOX gene effects on invasion andmetastasis of breast cancer cells by RNA interference. Methods: LOX-RNAi-LV was designed, ...

Compared with western populations, Southern Chinese, especially those residing in Hong Kong, areexperiencing increasing breast cancer incidence and also a younger onset of breast cancer. Combating thisproblem and treating ...

Curcumin (CM) possesses anti-cancer activity against a variety of tumors. Matrix metalloproteinases (MMPs)play an important role in remodeling the extracellular matrix and their activities are regulated by tissue inhibitorof ...