Pancreatic neuroendocrine tumors (pNETs) are rare and heterogenous tumors and surgery to remove theprimary tumor is the mainstay of treatment for resectable disease. However, curative surgery is often not feasible,because ...

Background: This systemic analysis was conducted to to evaluate the application value of positron emissiontomography/computed tomography (PET/CT) in early diagnosis of lung cancer. Methods: Clinical ...

Background: Serum vitamin D status can affect the prognosis of breast cancer patients. Our aim was todetermine the association between alterations in the 25-hydroxyvitamin D [25(OH)D] status during follow-upand the ...

Background: Many studies have reported associations of the X-ray repair cross-complementing group 3(XRCC3) Thr241Met polymorphism with colorectal cancer (CRC) risk, but the results remained controversial.Hence, we ...

Autophagy is a self-digestion process, wrapping cytoplasmic proteins or organelles to form vesicles fordegradation in lysosomes. The process plays an important role in the maintenance of intracellular homostasis. Herewe ...

The article provides an assessment of the dynamics of cancer incidence and mortality in the territory ofAktobe city for the period 2000-2010. The most common cancers were found in the lungs, stomach, esophagusand breast ...

Background: The effects of diet on epidemiology of prostate cancer are inconclusive. Therefore a hospitalbased,case-control study was conducted in a rural population of Faisalabad, Pakistan, to examine the impact ...

Background: Protrusive structures formed by migrating and invading cells are termed lamellipodia, filopodia,invadopodia and podosomes. Lamellipodia and filopodia appear on the leading edges of migrating cells ...

Cancer is a multifaceted and genomically complex disease and rapidly accumulating high impact researchis deepening our understanding related to the mechanisms underlying cancer development, progression andresistance to ...

Necroptosis, also known as “programmed necrosis”, has emerged as a critical factor in a variety of pathologicaland physiological processes and is considered a cell type-specific tightly regulated process with mechanismsthat ...

Background: Registry data from four major public hospitals indicate trends in clinical care and survivalfrom colorectal cancer over three decades, from 1980 to 2010. Materials and Methods: Kaplan-Meier ...

Background: Combination chemotherapy of 5 fluorouracil (5-FU) and leucovorin (LV) with oxaliplatin,mainly FOLFOX regimens, has shown considerable antitumor activity and a tolerable toxicity profile in gastriccancer. ...

Background: There are few choices for treatment of advanced cancer patients who do not respond to or tolerateconventional anti-cancer treatments. Therefore this study aimed to deploy the benefits and clinical efficacy ...

Objective: The aim of this retrospective study was to evaluate the feasibility and efficacy of response tocontinuous-infusion ifosfamide and doxorubicin combination as second-line chemotherapy for patients ...

Background: Despite the increasing number of screening examinations performed for cervical cancer utilizingthe Papanicolaou smear test (Pap test), few studies have examined whether this strategy is cost-effective ...

Curcumol is a sesquiterpene originally isolated from curcuma rhizomes, a component of herbal remediescommonly used in oriental medicine. Its beneficial pharmacological activities have attract significant interestrecently. ...

Colon cancer is one of the leading causes of cancer-associated death worldwide. The prognosis for advancedcolorectal cancers remains dismal, mainly due to the propensity for metastatic progression. Accordingly, thereis a ...

In this study, the antiproliferative effects of the metformin was evaluated on MCF-7 Cells (human breastadenocarcinoma cell line). For this purpose cell kinetic parameters including cell proliferation assay, mitoticindex ...

Purpose: To investigate effects of the TESTIN (TES) gene on proliferation and migration of highly metastaticnasopharyngeal carcinoma cell line 5-8F and the related mechanisms. Materials and Methods: The target ...

Background: The cancer of the prostate risk assessment (CAPRA) score has been defined to predict prostatecancer recurrence based on the pre-clinical data, then pathological data have also been incorporated. Thus,CAPRA ...