Soybean feeding improves vascular dysfunction and atte-nuates oxidative stress in streptozotocin-diabetic rats

Abstract

Background and Objective: In this research, the effect of chronic dietary soybean aqueous extract on aortic reactivity of streptozotocin (STZ)-diabetic rats was investigated. Materials and Methods: STZ-diabetic rats were treated with soybean aqueous extract for two months after diabetes induction. Contractile reactivity to KCl and phenylephrine (PE) and relaxation response to acetylcholine (ACh) were obtained from aortic rings and involved mechanisms were investigated. Results: Maximum contractile response of endothelium-intact rings to PE was significantly lower in soybean extract-treated diabetics relative to control diabetics (pConclusion: Chronic dietary treatment with soybean extract of diabetic rats attenuated some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and attenuation of oxidative stress in aortic tissue.