TERATOGENIC EFFECTS OF A NEW QUINAZOLINONE DERIVATIVE ON THE DEVELOPMENT OF BALB/C MICE FETUSES ON DAYS 9 10 AND 11 OF GESTATION

Abstract

For the first time, a spectrum of morphological abnormalities have been produced in developingmouse embryos (N=50), by injecting (IP) 75 and 100 mg/kg of maternal body weight of a new quinazolinonederivative, 4(3H)quinazolinone-2-propyl-2-phenylethyl(QPPE), on days 9, 10 and 11 of gestation.Measurements of the length of the crown-rump (CR), weight of body of the embryos and placenta on day 17showed significant growth retardation (P