10-year Graft Survival Analysis of Renal Transplantation and Factors Affecting it in Patients Transplanted from Live Donor in Shiraz Transplant Research Center during 1999-2009

Abstract

Background & Aims: Renal transplantation is the best therapeutic option for End Stage Renal Disease (ESRD). The aim of this study was to determine the graft survival rate of renal transplantation in patients who have been transplanted from live donor in Shiraz Transplant Research Center, Shiraz, Iran. Methods: In a survival analysis study, organ survival rate after kidney transplantation from live donor was determined in 843 patients being transplanted in Shiraz Transplant Research Center, Iran during a period of 10 years (March 1999 to March 2009). Kaplan-Meier method was used to determine the survival rate, Logrank test was used to compare survival curves and Cox proportional hazard model was used for multivariate analysis. Results: Mean follow-up period (± Standard deviation) was 53.07±34.6 months. Allograft survival rates at 1, 3, 5, 7 and 10 years after kidney transplantation were found to be 98.3%, 96.4%, 92.5%, 90.8% and 89.2%, respectively. Using Cox proportional hazard model, age of donor and creatinine level at discharge showed significant relationships with survival rate of renal allograft. Conclusion: The 10- year graft survival rate of renal transplantation from live donor in this center is 89.2% which in comparison with reports from large centers of transplantation it is satisfactory