Effect of hydro alcoholic extract of artichoke on diabetes treatment and liver enzymes in diabetic adult male rats

Abstract

Background and aims: Artichoke (<em>Cynara scolymus</em> L.) is a plant of the Asteraceae family. This plant is used in herbal medicine. This study was conducted to evaluate the effect of artichokeextract on insulin, glucagon, glucose, alkaline phosphatase (ALP), alanine amino transferase (ALT) and aspartate amino transferase (AST) in streptozotocin-induced diabetic rats. Methods: In this experimental study, 40 adult male Wistar rats weighting 220-200 g were used. The rats were divided into 4 equal groups including, control, diabetic and 2 diabetic experimental groups. Two experimental groups respectively received 100 and 300 mg/kg of artichoke hydro ethanol extract as intraperitoneal for 6 days. Diabetes was induced by intraperitoneal injection of 60 mg/kg streptozotocin. At the end of the sixth day, blood was taken from the heart of animals. Afterward serum concentration of insulin, glucagon, glucose, ALP, ALT and AST were measured. Then, the parameters measured in the different groups were compared with a control group. Data were evaluated by ANOVA, Duncan test and Student^'s t-test. Results: Results showed that artichoke extract significantly reduced the levels of glucagon, glucose, ALP, ALT, AST and increased insulin level compared to control and diabetic groups. It is worth noting that before the experiment, parameters tested were equal in all groups. Conclusion: Artichoke reduces blood sugar so it has a role in treatment of diabetes. Additionally, this herb is effective in control of blood glucose by liver enzymes reducing.