Effects of ionic parameters on behavior of a skeletal muscle fiber model

Abstract

All living cells have a membrane which separates inside the cell from it's outside. There is a potential difference between inside and outside of the cell. This potential difference will change during an action potential. It is quite common to peruse action potentials of skeletal muscle fibers with the Hodgkin-Huxley model. Since Hodgkin and Huxley summarized some controlling currents like inward rectifier current or chloride current as a leak current when we try to study the sensitivity of model to some parameters we lose some details. In this paper we use a model which contains sodium, potassium, chloride, Na-K pump, and inward rectifier currents. Firstly, we find critical point of the system, and discuss on how action potential changes for different initial values of variables. Then we study sensitivity of the critical point and maximum of potential to different parameters.