Drug Delivery study of Tamoxifea with Single Walled Carbon Nanotobes

Abstract

As drug delivery systems Nanoparticulan widely investigated because of many advantages such as smaller size,<br />controlled drug release potentiaL targeting ability, enhancement of therapeutic efficacy and reduction of<br />toxicity. So, carbon nanotubes have recently received considerable attention as alternative drug delivery carrier<br />In this study we investigate interaction of tamoxifen with open-end of shgle-walled carbon nanotubes (SWNTs)<br />using the Gaussian 98 program. We have computed NMR shielding tensors at BILTP and HF levels by using 3-<br />21G and 570-36 basis sets in the water. Our results reveal that NMR chemical shielding parameters are<br />strongly affected by inducing solvent media. Regarding to our plotted graph f pp, do, , 8 in different<br />methods and basis sets, the largest crw values obtained for Op atom at the 11F in STO-30 whereas the smallest<br />one belonged to Cp. It is interestusg to note that the opposite trend have been observed for asymmetry<br />parameterseaL