The kinetic parameters of drug compounds adsorption onto mesoporous materials

Abstract

The discovery of mesoporous molecular sieves, MCM-41, which possesses a regular hexagonal<br />array of uniform pore openings, aroused a worldwide resurgence in this field. This is not only<br />because it has brought about a series of novel mesoporous materials with various compositions<br />which may find applications in catalysis, adsorption, and guest-host chemistry, but also it has<br />opened a new avenue for creating of the zeotype materials. This paper presents a comprehensive<br />overview of recent advances in the field of MCM-41. Adsorption of drug molecules such as<br />Pseudeoephedrine hydrochloride onto mesoporous molecular sieves (MCM-41) from aqueous<br />solution has been investigated systematically using batch experiments in this study. Results<br />indicate that Pseudeoephedrine hydrochloride adsorption is initially rapid and the adsorption<br />process reaches a steady state after 2 min. The adsorption isotherms are well described by the<br />Langmuir model. Based on the results, it suggests that the adsorption is primarily brought about by<br />hydrophobic interaction between drug molecules and MCM-41 surface.