In-vitro Antibacterial Evaluation of Some Fluoroquinolone Derivatives Against Food Borne Bacteria

Abstract

Food poisoning has been emerged as a worldwide health issue and related illness in both developed and developing countries confirms its significance as an important public health priority.<em>In vitro</em> antibacterialevaluationof nine fluoroquinolone derivatives against food borne bacteria including Gram-positive (<em>Staphylococcus aureus</em>) and Gram-negative (<em>Salmonella enterica</em>, <em>Escherichia coli</em>, <em>Yersinia enterocolitica</em>, <em>Vibrio </em><em>cholerae</em>) organisms was developed using agar dilution technique and compared with ciprofloxacin and norfloxacin as reference drugs.Most compounds showed good activity against Gram-positive and the Gram-negative bacteria. All compounds were active against <em>Staphylococcus aureus</em> (MIC=3.12-6.12µg/mL) and compounds 1a, 1c-e, 2a, and 3c(MIC=3.12µg/mL) exhibited excellent antibacterial activity in comparison to ciprofloxacin and norfloxacin (MIC=6.25µg/mL). Fluoroquinolone derivatives exhibited good activity against food borne bacteria and are appropriate candidates for food poisoning prevention.