Synthesis and study of structural and magnetic properties of superparamagnetic Fe3O4@SiO2 core/shell nanocomposite for biomedical applications

Abstract

Objective(s): <br/>This paper describes coating of magnetite nanoparticles (MNPs) with amorphous silica shells. <br/> <br/>Materials and Methods: <br/>First, magnetite (Fe₃O₄) NPs were synthesized by co-precipitation method and then treated with stabilizer molecule of trisodium citrate to enhance their dispersibility. Afterwards, coating with silica was carried out via a sol-gel approach in which the electrostatically stabilized MNPs were used as seeds. The samples were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy and vibrating sample magnetometer (VSM). <br/>Results: <br/>The results of XRD analysis implied that the prepared nanocomposite consists of two compounds of crystalline magnetite and amorphous silica that formation of their core/shell structure with the shell thickness of about 5 nm was confirmed by TEM images. The magnetic studies also indicated that produced Fe₃O₄@SiO₂ core/shell nanocomposite exhibits superparamagnetic properties at room temperature. <br/>Conclusion: <br/>These core/shell structure due to having superparamagnetic property of Fe₃O₄ and unique properties of SiO₂, offers a high potential for many biomedical applications.