A Case of Metformin-Related Megaloblastic Anemia Presenting with Palpitation

Abstract

<br/>Introduction:Metformin is the cornerstone of medical treatment in most diabetic patients with many beneficial effects on cardio-metabolic parameters. However, long term metformin is a known pharmacological cause of vitamin B₁₂ deficiency leading to neurological symptoms, megaloblastic anemia and increased levels of serum homocysteine. Moreover, it is well known that vitamin B₁₂ deficiency-induced neurologic symptoms precede the appearance of megaloblastic anemia. <br/>Case:We herein report the case of an old woman with a history of long term metformin consumption who visited the cardiology clinic with the chief complaint of palpitation due to megaloblastic anemia without any neuropsychiatric symptoms. She was successfully treated with a parenteral regimen of vitamin B₁₂ within two months. <br/>Conclusion:Although annual measurement of serum vitamin B₁₂ levels could be considered in patients on long-term metformin therapy, yet it seems more reasonable and cost-effective to prevent vitamin B₁₂ deficiency and its related adverse effects with annual prescription of parenteral vitamin B₁₂ in all such patients.