Fabrication of Thiazole Based Heterocyclic Azo Dye Modified Carbon Paste Electrode for Detection of Dopamine: A Voltammetric Study

Abstract

A 5-[(4-phenyl-1, 3-thiazol-2yl) diazenyl] 1,3diazinane 2, 4,6trione (PTDDT) was synthesized from 2-amine-4-phenylethioazole. The synthesized PTDDT was characterized through using mass, UV-Visible, 1H NMR, 13C NMR, elemental analysis and FT-IR. Characterized PTDDT used as a modifier for carbon paste electrode (CPE) and was used for voltammetric detection of dopamine (DA) and uric acid (UA) using phosphate buffer solution (PBS) at pH 6.6. Many different parameters were studied such as sweep rate, varied concentration, pH study. The limit of detection is 1.056 µM for DA and 0.080 µM for UA with a limit of quantification 3.521 µM for DA and 0.267 µM for UA at PTDDT/MCPE, and it also shows good repeatability and satisfactory recovery result on real samples.