Functionalized Melissa Plant Extract-Mediated Al2O3/Fe2O3 Nanocomposite Potentiometric Sensor for Determination of Diphenhydramine

Abstract

A sensitive, simple, cost-effective, and eco-friendly method has been suggested for the determination of the drug diphenhydramine (DPH) in pure and pharmaceutical formulations. The method depended on the preparation of the nano-aluminum oxide (Al2O3 NPs) and nano-iron oxide (Fe2O3 NPs) using the Melissa plant extract. The main purpose of this study is to determine the extent of change in electrical potential by using copper wire and aluminum wire, four electrodes were prepared. All electrodes showed Nernstian response, the best response was equal to 57.75 mv/decade for the electrode made from (sodium tetraphenylborate STPB- diphenhydramine) as an ion pair with TBP as a plasticizer and (Al2O3 /Fe2O3) NPS with the aluminum wire membrane electrode, also the concentration range was 1.0×10-2 to 1.0×10-8 mole.L-1 with detection limit near to 2.07×10-7 mole.L-1. The value of the correlation coefficient (R2) was 0.9998. In this study, we succeeded in producing nanomaterials from green sources, with applied them in the potentiometric determination of the drug (DPH) to increase the sensitive of the preparation electrodes. These methods have become more desirable because they are characterized by ease of preparation, low cost, and do not use materials harmful to the environment.