Purpose: We made a preliminary attempt to study mutations in exons 5-8 (the DNA binding domain) ofthe tumor suppressor gene TP53, in urinary bladder cancer patients from Kashmir. Further the relation ofclinicopathological ...

Background: Tumor suppressor gene (TP53) is considered as the most frequently mutated gene in almost all forms of human cancer. Moreover, genetic variations in the XPD gene affect the DNA repair capacity increasing cancer ...

TP53 is the mostly commonly mutated gene in many cancers and the P53 tumor suppressor protein is involvedin multiple cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle ...

Objective: To assess associations between codon 72 polymorphisms (Pro or B and Arg or b alleles) of theTP53 gene and lung cancer risk among Bangladeshis. Materials and Methods: The distribution of ...

Objective: This study aimed at exploring the association of TP53 72Arg/Pro polymorphism and Risk of ChronicLymphocytic Leukemia and to assess the correlation between TP53 72Arg/Pro polymorphism and clinical parameter,

Background:

Background: TP53 mutations are the most common genetic alterations in human cancers. There are alsoseveral polymorphisms in both exons and introns of TP53 that may influence its anti-tumor functions and increasethe ...

Background: The purpose of this study was to evaluate the potential association of five (p.P47S, p.R72P, PIN3 Ins16bp, p.R213R and r.13494g>a) polymorphisms of TP53 with the risk of developing breast cancer in North ...

Recent advances in molecular biology make the identification of prostate cancer (PC) subsets a priority for more understanding of the molecular pathogenesis and treatment options. Genetic alterations in many genes such as ...

Background: Breast cancer (BC) is a leading female cancer worldwide and cause of cancer-related death, especially in developing countries. Genetic predispositions to BC development in African population is poorly studied, ...

Background: Genetic polymorphisms of TP63 have been suggested to influence susceptibility to lungadenocarcinoma development in East Asian populations. This study aimed to investigate the relationship betweencommon ...

The development of motorcycle industry in Indonesia is quite rapid. The mode of transportation is a favorite the people of Indonesia, especially in industrial area. The average motorcycle user is a company employee because ...

Background: The pharmacogenetic-oriented approach reduces the toxicity and increases the safety of chemotherapeutic agents. 6-mercaptopurin (6-MP) metabolizing enzymes such as thiopurine S-methyltransferase (TPMT) and ...

Abstract Manufacturing companies must find competitive methods to produce products cheaper, faster and better to continuously satisfy their customers and acquire organizational success. For continuous improvement to ...

To determine the factors affecting the outcome of patients with traumatic acute subdural hematoma, we reviewed the records of7 4 consecutive comatose patients with a Glascow coma scale Score (GCS) of less than 8 who had ...

Background: The trabecular bone changes in the tibia of C3H/HeN mice were measured 12 weeks after whole body irradiation with various doses of fast neutrons (0-2.4 Gy) or 137Cs-generated gamma-rays (0-6 Gy). Materials and ...

This study describes a new simple, sensitive and selective catalytic kinetic spectrophotometricmethod for the determination of vanadium (V). The method is based upon the catalytic effect ofvanadium (V) on the ...

A simple, accurate and fast vortex-assisted dispersive liquid-liquid microextraction procedure has been developed for the extractive spectrophotometric determination of niflumic acid in biological samples. The method is ...