ارزش تشخیصی سطح سرمی انزیم های ADA، GGT و ALP در تشخیص و پیش اگهی سرطان سینه،یک مطاله سه مرکزی

Abstract

Introduction: Breast cancer accounts for the most common cancer in urban Indian females, and the second commonest in the rural Indian women. Early detectable cancers can potentially be cured when the tumour is small enough to be completely removed surgically. A number of biochemical tumour markers have been studied for the early detection of cancer. However these facilities are only available at sophisticated and well equipped centers with latest technology and they are also expensive. Methods: This was a case-control comparative study conducted taking 26 clinically and histopathologically established female breast cancer patients. The cases will first be categorized according to the TNM staging of Ca Breast. Serum was collected for estimation of ADA, GGT and liver enzymes (SGOT, SGPT, and ALP) and lipid profile. Results: There was significant increase in the mean serum ADA, GGT & ALP levels in carcinoma breast patients in comparison to healthy controls. Inter-stage comparison of serum ADA, GGT & ALP level in various stages also showed significant hike. Results: There was significant increase in the mean serum ADA, GGT & ALP levels in carcinoma breast patients in comparison to healthy controls. Inter-stage comparison of serum ADA, GGT & ALP level in various stages also showed significant hike. Conclusion: The extent of rise in these parameters can be taken as one of the important criteria to establish its diagnostic role in carcinoma Breast patients. These might prove to be easily accessible and affordable biomarkers in remote areas for the early detection of the disease.