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    • دوره 2, شماره 1
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    Evaluation of Occupational Exposure with Vinyl Chloride Monomer in the Plastic Products Industry in Tehran

    (ندگان)پدیدآور
    رعنا طایفه رحیمیانمنصور رضازاده آذریمحمد جواد جعفریحمید سوریبهزاد سرانجامالهه توکلمحمد کریمی
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    چکیده
    Backgrounds and Objective: Growth of the plastics industry in recent decades has been dramatic. Poly Vinyl Chloride is one of the most widely used plastics in the world that granules in the thermal process decompose to Vinyl Chloride Monomer and is released in work air environment. This study aimed to evaluate occupational exposure and estimate workers' exposure to vinyl chloride monomer risk. Materials and Methods: A cross-sectional study of 100 workers at two Plastic factories in Tehran (A, B) was performed. Personal monitoring of workers to Vinyl Chloride Monomer was conducted by Optimized Method No.1007 from NIOSH. Atmospheric conditions, such as temperature, pressure, air velocity, and relative humidity were measured simultaneously along with personal monitoring. Quantitative risk assessment of workers was computed in the form of Standard Mortality Rate and incident rate cancer. Statistical analysis of data was conducted by SPSS version 19. Results: Climatic parameters in the plant A and B for a relative humidity were 43.77± 16.71 and 37.16±14.45 % and temperature 20.95± 3.34 and 21.05± 2.20 ºC, air pressure 87.48 ± 0.54 and 87.41 ± 0.64 kPa and air velocity 0.13± 0.08 and 0.10 ± 0.06 meters per second were measured respectively. Occupational exposure to Vinyl Chloride Monomer plants A and B were 1.01 ± 0.51 and 0.72 ± 0.30 as ppm respectively. Quantitative risk of exposed workers based on Standard Mortality Rate was estimated 1.06 ± 0.03 times of the population without exposure. Incident rate cancer based on accounting measures of Integrated Risk Information System was calculated per 1000 person exposure population. The correlation of Standard Mortality Rate and the risk of cancer incidence was statistically significant (R2 =0.88). Conclusion: Thirty one percent of workers had higher exposure to Vinyl Chloride Monomer than the occupational exposure limits (1 ppm). In the present workers’ exposure in this study is lower than international workforces reported in decades ago, but higher than studies recently published. The results clearly describe occupational hazard of workers in the current Iranian recession situation. Therefore, risk management of workers’ health in these industries is imperative, especially in the coming years with projected economic growth. REFERENCES 1. Andrady AL, Neal MA. Applications and societal benefits of plastics. Philosophical Transactions of the Royal Society B: Biological Sciences. 2009;364(1526):1977-84.2. Thompson RC, Moore CJ, vom Saal FS, Swan SH. Plastics, the environment and human health: current consensus and future trends. Philosophical Transactions of the Royal Society B: Biological Sciences. 2009;364(1526):2153-66.3. Thompson RC, Swan SH, Moore CJ, vom Saal FS. Our plastic age. Philosophical Transactions of the Royal Society B: Biological Sciences. 2009;364(1526):1973-6.4. Agancy for Toxic Substances and Disease Registry (ATSDR) .Toxicological profile for vinyl chloride. 2006. [cited july 2012 ; Available from:http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=282&tid=51].5. Elliott P, Kleinschmidt I. Angiosarcoma of the liver in Great Britain in proximity to vinyl chloride sites. Occupational and environmental medicine. 1997;54(1):14-8.6. Falk H, Herbert J, Crowley S, Ishak KG, Thomas LB, Popper H, et al. Epidemiology of hepatic angiosarcoma in the United States: 1964-1974. Environmental health perspectives. 1981;41:107.7 .Lester D, Greenberg L, Adams WR. Effects of single and repeated exposures of humans and rats to vinyl chloride. American Industrial Hygiene Association Journal. 1963;24(3):265-75.8. Mastromatteo E, Fisher A, Christie H, Danziger H. Acute inhalation toxicity of vinyl chloride to laboratory animals. American Industrial Hygiene Association Journal. 1960;21(5):394-8.9 .Fučić A, Horvat D, Dimitrović B. Mutagenicity of vinyl chloride in man: comparison of chromosome aberrations with micronucleus and sister-chromatid exchange frequencies. Mutation Research/Genetic Toxicology. 1990;242(4):265-70.10. Leonard A, Decat G, Leonard E, Lefevre M, Decuyper L, Nicaise C. Cytogenetic investigations on lymphocytes from workers exposed to vinyl chloride. Journal of Toxicology and Environmental Health, Part A Current Issues. 1977;2(5):1135-41.11. Qiu Y-l, Wang W, Wang T, Liu J, Sun P, Qian J, et al. Genetic Polymorphisms, Messenger RNA Expression of p53, p21, and CCND1, and Possible Links with Chromosomal Aberrations in Chinese Vinyl Chloride–Exposed Workers. Cancer Epidemiology Biomarkers & Prevention. 2008;17(10):2578-84.12. Zhu S, Wang A, Xia Z. Polymorphisms of DNA repair gene XPD and DNA damage of workers exposed to vinylchloride monomer. International journal of hygiene and environmental health. 2005;208(5):383-90.13. Bao Y. The effects of vinyl chloride on pregnancy parturition and fetal development among female workers]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 1988;22(6):343.14. Barakat RA, Bakery H, Salem MA, Abdelaleem NM. Early Investigation of Hepatocarcinogenic Effect of Polyvinyl Chloride in Rat. Global Veterinaria. 2014;12(1):67-75.15. Awara WM, El-Nabi SH, El-Gohary M. Assessment of vinyl chloride-induced DNA damage in lymphocytes of plastic industry workers using a single-cell gel electrophoresis technique. Toxicology. 1998;128(1):9-16.16. Smolianskiene G. Exposure assessment of vinyl chloride monomer in the workplace air of Lithuanian industries. Annals of occupational Hygiene. 2002;46(suppl 1):456-9.17. Azari MR, Nasermoaddeli A, Movahadi M, Mehrabi Y, Hatami H, Soori H, et al. Risk assessment of lung cancer and asbestosis in workers exposed to asbestos fibers in brake shoe factory in Iran. Industrial health. 2010;48(1):38-42.18. Azari MR, Rokni M, Salehpour S, Mehrabi Y, Jafari MJ, Moaddeli AN, et al. Risk assessment of workers exposed to crystalline silica aerosols in the east zone of Tehran. Tanaffos. 2009;8(3):43-50.19. Swaen G, de Hollander A, Kroes R, den Engelse L, Feron V, Mulder G, et al. A scientific basis for the risk assessment of vinyl chloride. Regulatory Toxicology and Pharmacology. 1987;7(1):120-7.20. Hsieh H-I, Chen P-C, Wong R-H, Du C-L, Chang Y-Y, Wang J-D, et al. Mortality from liver cancer and leukaemia among polyvinyl chloride workers in Taiwan: an updated study. Occupational and environmental medicine. 2011;68(2):120-5.21. Integrated Risk Information System(IRIS). vinyl chloride. 2000 [cited 10 may 2012 ; Available from:http://www.epa.gov/iris/subst/1001.htm].22. Matsumura Y. Adsorption capacities of active carbon tubes for sampling atmospheric vinyl chloride vapor. Industrial health. 1980;18(2):61-7.23. Theriault G, Allard P. Cancer mortality of a group of Canadian workers exposed to vinyl chloride monomer. Journal of Occupational and Environmental Medicine. 1981;23(10):671-6.24. American Conference of Governmental Industrial Hygienists  (ACGIH). TLVs and BEIs Based on the Dcumentation of the Thershold Limit Values for chemical Substances and Physical Agent & Biological Exposure Indices. 2013. [Available from: http://www.acgih.org/store/ProductDetail.cfm?id=2233].25. Hagmar L, Kesson B, Nielsen J, Andersson C, Lindan K, Attewell R, et al. Mortality and cancer morbidity in workers exposed to low levels of vinyl chloride monomer at a polyvinyl chloride processing plant. American journal of industrial medicine. 1990;17(5):553-65.26. Starnes Jr W. Structural and mechanistic aspects of the thermal degradation of poly (vinyl chloride). Progress in Polymer Science. 2002;27(10):2133-70.
    کلید واژگان
    صنعت پلاستیک
    مونومر وینیل کلراید
    پایش فردی
    ارزیابی ریسک

    شماره نشریه
    1
    تاریخ نشر
    2014-07-16
    1393-04-25
    ناشر
    دانشگاه علوم پزشکی شهید بهشتی
    سازمان پدید آورنده
    Faculty of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Safety Promotions and Injury Prevention Research Center of Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Faculty of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Safety Promotions and Injury Prevention Research Center of Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Faculty of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Faculty of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Fajr Petrochemical Companies, Bandar mahshahr, Iran

    شاپا
    2345-2455
    2383-1901
    URI
    https://dx.doi.org/10.22037/meipm.v2i1.6469
    https://journals.sbmu.ac.ir/spip/article/view/6469
    https://iranjournals.nlai.ir/handle/123456789/777884

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