Modulation of blood hemostasis by concurrent training in obese women with low-mobility

Abstract

Background & Aims: Obesity is a risk factor for the development of cardiovascular diseases; it can in part be explained by a disturbance in the blood hemostasis. The balance of the coagulation and fibrinolysis factors has an important role in maintaining hemostasis. Thus, the aim of this study was to modulate blood hemostasis by concurrent training in obese women with low-mobility. Materials & Methods: 20 women (25-30 years, BMI>30 kg/m2) with low mobility were randomly divided into control and concurrent training groups. Concurrent training was performed at 23 minutes sub-maximal aerobic training, two sets with 10 repetitions of 10RM resistance exercise for 8 weeks. Coagulation and fibrinolysis factors were measured using the ELISA kits. Analysis of data performed using dependent t-test and Analysis of variance. Results: In concurrent training, fibrinolysis factors like t-PA (p=0.001), plasminogen, and D-dimer (p=0.001) increased significantly. Coagulation factors (fibrinogen and PTT) decreased significantly (p=0.001); however, PAI-1 (p=0.001) and PT (p=0.001) increased significantly. Conclusion: The results of this study showed that fibrinolysis factors affected by concurrent training because, in this type of training, the combination of the effect of aerobic training on plasma volume and resistance training on blood proteins improves fibrinolysis. Further studies are suggested about the effect of this type of training on coagulation factors.